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Russian Journal of Bioorganic Chemistry

, Volume 26, Issue 2, pp 71–84 | Cite as

Intracellular proteolysis: Signals of selective protein degradation

  • N. N. Starkova
  • E. P. Koroleva
  • T. V. Rotanova
Review Articles
  • 82 Downloads

Abstract

Selective proteolysis is one of the mechanisms for the maintenance of cell homeostasis via rapid degradation of defective polypeptides and certain short-lived regulatory proteins. In prokaryotic cells, high-molecular-mass oligomeric ATP-dependent proteases are responsible for selective protein degradation. In eukaryotes, most polypeptides are attacked by the multicatalytic 26S proteasome, and the degradation of the majority of substrates involves their preliminary modification with the protein ubiquitin. The proteins undergoing the selective proteolysis often contain specific degradation signals necessary for their recognition by the corresponding proteases.

Key words

selective proteolysis ATP-dependent proteases proteasome degradation signals 

Abbreviations

ODC

ornithine decarboxylase

Tsp

tail-specific protease

Ub

ubiquitin

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Copyright information

© MAIK “Nauka/Interperiodica” 2000

Authors and Affiliations

  • N. N. Starkova
    • 1
  • E. P. Koroleva
    • 1
  • T. V. Rotanova
    • 1
  1. 1.Shemyakin-Ovchinnikov Institute of Bioorganic ChemistryRussian Academy of SciencesGSP-7 MoscowRussia

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