Abstract
Organic-mineral composites prepared by 121‡C heat treatment of aqueous suspensions of hydroxy-propylmethylcellulose (HPMC) and calcium dibasic phosphate dihydrate, nonstoichiometric hydroxyapatite, or a two-phase calcium phosphate were characterized by IR spectroscopy, scanning electron microscopy, x-ray diffraction, and chemical analysis with the aim of assessing the reactivity of the inorganic and organic phases. The results demonstrate that, under the experimental conditions used, there is no chemical interaction between the calcium phosphates studied and HPMC.
Similar content being viewed by others
References
LeGeros, R.Z., Calcium Phosphate Materials in Restorative Dentistry: A Review,Adv. Dent. Res., 1988, vol. 2, pp. 164–183.
Rey S. Calcium Phosphate Biomaterials and Bone Mineral: Differences in Composition, Structure, and Properties,Biomaterials, 1990, vol. 11, pp. 13–16.
Suchanek, W. and Yoshimura, M., Processing and Properties of Hydroxyapatite-Based Biomaterials for Use as Hard Tissue Replacement Implants,J. Mater. Res., 1998, vol. 13, pp. 94–117.
Boulignand, Y. and Giraud-Guille, M.M., Spatial Organization of Collagen Fibrils in Skeletal Tissue: Analogies with Liquid Crystals,Biology of Invertebrate and Lower Vertebrate Collagens, Bairati, A. and Garrone, R., Eds., New York: Plenum, 1985, pp. 115–134.
Glimcher, M.J., The Nature of the Mineral Phase in Bone: Biological and Clinical Implications, inMetabolic Bone Disease, New York: Academic, 1998, pp. 23–50.
LeGeros, R.Z., Calcium Phosphates in Oral Biology and Medicine,Monographs in Oral Science, Myers, H., Ed., Basel: Karger, 1991, vol. 15.
Elliott, J.C., Structure and Chemistry of the Apatites and Other Calcium Orthophosphates, inStudies in Inorganic Chemistry, Amsterdam: Elsevier, 1994, vol. 18.
Lin, H., Yanagi, T., Seo, W.S.,et al., Crystal Growth of Hydroxyapatite under Two-Dimensionally Oriented Organic Films,Bioceramics, 1996, vol. 9, pp. 371–374.
Hunter, G.K. and Goldberg, H.A., Nucleation of Hydroxyapatite by Bone Sialoprotein,Proc. Natl. Acad. Sci. U. S. A., 1993, vol. 90, pp. 8562–8565.
Boskey, A.L., Osteopontin and Related Phosphorylated Sialoproteins: Effects on Mineralization,Annu. Rev. NY Acad. Sci., 1995, vol. 760, pp. 249–256.
Hunter, G.K. and Goldberg, H.A., Modulation of Crystal Formation by Bone Phosphoproteins: Role of Glutamic Acid-Rich Sequences in the Nucleation of Hydroxyapatite by Bone Sialoprotein,Biochem. J., 1994, vol. 302, pp. 175–179.
Ngankam, P.A., Shaaf, P., Voegel, J.-C, and Cuisinier, F.J.G., In Situ Investigation of Heterogeneous Nucleation of Hydroxyapatite Studied by S.A.R.,J. Dent. Res., 1998, vol. 77, spec, issue B, p. 917.
Stupp, S.I. and Braun, P.V., Molecular Manipulation of Microstructures: Biomaterials, Ceramics, and Semiconductors,Science (Washington, D. C., 1883-), 1997, vol. 277, pp. 1242–1248.
Walsh, D. and Mann, S., Chemical Synthesis of Microskeletal Calcium Phosphate in Bicontinuous Microemulsions,Chem. Mater., 1996, vol. 8, pp. 1944–1953.
Tanahashi, M., Yao T., Kokubo T.,et al., Apatite Coating on Organic Polymers by a Biomimetic Process,J. Am. Ceram. Soc, 1994, vol. 77, pp. 2805–2808.
Li, P.J., Bakker, D., and vanBlitterswijk, CA., A Hydroxyapatite-Polymer Composite Prepared by Mimicking Bone Mineralization,Bioceramics, 1995, vol. 8, pp. 435–439.
LeGeros, R.Z., Retino, M., Mijares, D.,et al., Carbon-atehydroxyapatite (CHA)/Polymer Interactions,J. Dent. Res., 1998, vol. 77, spec. issue B, p. 916.
Bigi, A., Panzavolta, S. and Roveri, N., Hydroxyapatite-Gelatin Films: A Structural and Mechanical Characterization,Biomaterials, 1998, vol. 19, pp. 739–744.
Privalov, V.I., Orlovskii, V.P., Slivka, O.I., and Razgonyaeva, G.A.,In Vitro Molecular Dynamics of Collagen Fibrils, Glycine, Hydroxyapatite, and Their Compounds from1H and31P NMR Data,Dokl. Akad. Nauk, 1998, vol. 361, no. 4, pp. 503–506.
Mucalo, M.R., Yokogawa, Y., Toriyama, M.,et al., Growth of Calcium Phosphate on Surface-Modified Cotton,J. Mater. Sci. Mater. Med., 1995, vol. 6, pp. 597–605.
Yokogawa, Y., Toriyama, M., Kawamoto, Y.,et al., Calcium Phosphate Compound-Cellulose Fiber Composite Material Prepared in Soaking Medium at 36.5-60‡C,J. Mater. Res., 1998, vol. 13, pp. 922–925.
Okazaki, M., Hattori, M., Takahashi, J. and Kimura, H., Specific Physicochemical Properties of Apatites: 9. Organic Phosphate Ester Monomer as a Source of P,ShikaZairyo Kikai, 1989, vol. 8, pp. 797–802.
Yamada, S., Heymann, D., Bouler, J.M. and Daculsi, G., Osteoclastic Resorption of Biphasic Calcium Phosphate Ceramic in Vitro,J. Biomed. Mater. Res., 1997, vol. 37, pp. 346–352.
Daculsi, G., Weiss, P., Delecrin, J.,et al., Int. Patent WO 95/21634, 1995.
Weiss, P., Lapkowski, M., LeGeros, R.Z.,et al., Fourier-Transform Infrared Spectroscopy Study of an Organic-Mineral Composite for Bone and Dental Substitute Materials,J. Mater. Sci. Mater. Med., 1997, vol. 8, pp. 621–629.
Grimandi, G., Weiss, P., Millot, F. and Daculsi, G.,In Vitro Evaluation of a New Injectable Calcium Phosphate Material,J. Biomed. Mater. Res., 1998, vol. 39, pp. 660–666.
Cherng, A., Takagi, S. and Chow, L.C., Effects of Hydroxypropylmethylcellulose and Other Gelling Agents on the Handling Properties of Calcium Phosphate Cement,J. Biomed. Mater. Res., 1997, vol. 35, pp. 273–277.
Powder Diffraction File, Swarthmore: Joint Committee on Powder Diffraction Standards.
Rey, S., Shimizu, M., Collins, B. and Glimcher, M.J., Resolution-Enhanced Fourier Transform Infrared Spectroscopy Study of the Environment of Phosphate Ions in the Early Deposits of a Solid Phase of Calcium Phosphate in Bone and Enamel, and Their Evolution with Age: 1. Investigations in the v4 PO4 Domain,Calcif. Tissue Int., 1990, vol. 46, pp. 384–394.
Rey, S., Shimizu, M., Collins, V. and Glimcher, M.J., Resolution-Enhanced Fourier Transform Infrared Spectroscopy Study of the Environment of Phosphate Ions in the Early Deposits of a Solid Phase of Calcium Phosphate in Bone and Enamel and Their Evolution with Age: 2. Investigations in the v3 PO4 Domain,Calcif. Tissue Int., 1991, vol. 49, pp. 383–388.
Chumaevskii, N.A., Orlovskii, V.P., Ezhova, Zh.A.,et al., Synthesis and Vibrational Spectra of Calcium Hydroxyapatite,Zh. Neorg. Khim, 1992, vol. 37, no. 7, pp. 1455–1457.
Ozin, G.A., Varaksa, N., Coombs, N.,et al., Bone Mimetics: A Composite of Hydroxyapatite and Calcium Dodecylphosphate Lamellar Phase,J. Mater. Chem., 1997, vol. 7, pp. 1601–1607.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dorozhkin, S.V. Unreactiveness of calcium phosphates and hydroxypropylmethylcellulose in organic-mineral composites. Inorg Mater 36, 1024–1031 (2000). https://doi.org/10.1007/BF02757979
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF02757979