, Volume 69, Issue 5, pp 536–540 | Cite as

Effect of microelements on the biosynthesis of secondary metabolites by the fungusPenicillium citrinum thom VKM F-1079

  • A. G. Kozlovskii
  • V. P. Zhelifonova
  • N. G. Vinokurova
  • S. M. Ozerskaya
Experimental Articles


Penicillium citrinum VKM F-1079 was found to produce clavine ergot alkaloids and citrinin, a secondaryO-heterocyclic metabolite. Citrinin was produced in the idiophase, whereas the production of ergot alkaloids paralleled fungal growth. The addition of manganese ions to the growth medium stimulated the biosynthesis of both citrinin and ergot alkaloids. Zinc ions stimulated only citrinin synthesis. The presence of these microelements in the growth medium influenced the proportion between the ergot alkaloids synthesized. Copper, manganese, and iron ions slightly affected fungal growth and alkaloid production. The effect of microelements on the main kinetic parameters of growth and alkaloid production was studied.

Key words

fungi physiology secondary metabolites clavine ergot alkaloids citrinin 


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Copyright information

© MAIK “Nauka/Interperiodica” 2000

Authors and Affiliations

  • A. G. Kozlovskii
    • 1
  • V. P. Zhelifonova
    • 1
  • N. G. Vinokurova
    • 1
  • S. M. Ozerskaya
    • 1
  1. 1.Skrjabin Institute of Biochemistry and Physiology of MicroorganismsRussian Academy of SciencesRussia

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