Paradoxical effect of dexamethasone administration to rabbits with antigen-induced arthritis
Systemic dexamethasone phosphate administration to rabbits 2 h before induction of arthritis by antigen promoted a decrease in cellular influx, vascular permeability and eicosanoid concentrations in the synovial fluids. When administered 24 h before the articular challenge a significant increase in all parameters assessed was observed. A third group of animals receiving an injection of dexamethansone before the intra-articular challenge. The results suggest that a blockade of the hypothalamic-pituitary-adrenal axis could be responsible for the findings in animals treated 24 h before induction of arthritis, and that endogenous glucocorticoids can be important for the down-regulation, of the articular inflammatory reaction.
Keywordsarthritis dexamethasone eicosanoids
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