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InflammoPharmacology

, Volume 1, Issue 4, pp 289–294 | Cite as

Paradoxical effect of dexamethasone administration to rabbits with antigen-induced arthritis

  • A. J. De Brum-Fernandes
  • V. De Falco
  • F. A. Castro da Rocha
  • S. Jancar
Article

Abstract

Systemic dexamethasone phosphate administration to rabbits 2 h before induction of arthritis by antigen promoted a decrease in cellular influx, vascular permeability and eicosanoid concentrations in the synovial fluids. When administered 24 h before the articular challenge a significant increase in all parameters assessed was observed. A third group of animals receiving an injection of dexamethansone before the intra-articular challenge. The results suggest that a blockade of the hypothalamic-pituitary-adrenal axis could be responsible for the findings in animals treated 24 h before induction of arthritis, and that endogenous glucocorticoids can be important for the down-regulation, of the articular inflammatory reaction.

Keywords

arthritis dexamethasone eicosanoids 

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References

  1. 1.
    Blackwell GJ, Carnuccio R, Di Rosa M, Flower RJ, Langham CSJ, Parente L, Persico P, Russel-Smith NC, Stone D. Glucocorticoids induce the formation and release of anti-inflammatory and anti-phospholipase proteins into the peritoneal cavity of the rat. Br J Pharmacol. 1982;76:185–94.PubMedGoogle Scholar
  2. 2.
    Carnuccio R, Di Rosa M, Flower RJ, Pinto A. The inhibition by hydrocortisone of prostaglandin biosynthesis in rat peritoneal leukocytes is correlated with intracellular macrocortin levels. Br J Pharmacol. 1981;74:322–4.PubMedGoogle Scholar
  3. 3.
    de Brum-Fernandes AJ, Bueno C, Oliveira RM. Rheumatoid factor in rabbits with antigen-induced arthritis. Braz J Med Biol Res. 1988;21:97–101PubMedGoogle Scholar
  4. 4.
    de Brum-Fernandes AJ, Lazzari AA, Oliveira RM, Bueno C. Antibodies to collagen in experimental antigen induced arthritis of the rabbit. J Rheumatol. 1988;15:483–5.PubMedGoogle Scholar
  5. 5.
    Cooke TD, Hurd ER, Ziff M, Jasin HE. The pathogenesis of chronic inflammation in experimental antigen-induced arthritis, II: Preferential localization of antigen-antibody complexes to collagen tissues. J Exp Med. 1972;135:323–38.PubMedCrossRefGoogle Scholar
  6. 6.
    Dumonde DC, Glynn LE. The production of arthritis in rabbits by an immunological reaction to fibrin. Br J Exp Pathol, 1962,;43:373–82.PubMedGoogle Scholar
  7. 7.
    Gall EP, Gall EA. Histopathogenesis of bovine serum albumin-induced arthritis in the rabbit. J Rheumatol. 1980;7:13–23.PubMedGoogle Scholar
  8. 8.
    Heymer PM, Spanel R, Haferkamp O. Experimental models of arthritis. Curr Top Pathol. 1982;71:123–52.PubMedGoogle Scholar
  9. 9.
    Jasin HE, Ziff M. Immunoglobulin and specific antibody synthesis in a chronic inflammatory focus: antigen-induced synovitis. J Immunol. 1969;102:355–67.PubMedGoogle Scholar
  10. 10.
    Henderson B, Higgs GA, Moncada S, Salmon JA. Synthesis of eicosanoids by tissues of the synovial joint during the development of chronic erosive synovitis. Agents Actions. 1985;17:360–2.CrossRefGoogle Scholar
  11. 11.
    Henderson B, Higgs GA. Synthesis of arachidonate oxidation products by synovial joint tissues during the development of chronic ersive arthritis. Arthritis Rheum. 1987;30:1149–56PubMedCrossRefGoogle Scholar
  12. 12.
    Flower RJ, Parente L, Persico P, Salmon JA. A comparison of the acute inflammatory response in adrenalectomised and sham-operated rats. Br J Pharmacol. 1986;87:57–62.PubMedGoogle Scholar
  13. 13.
    Garcia Leme J, Wilhelm DL. The effects of adrenalectomy and corticosterone on vascular permeability responses in the skin of the rat. Br J Exp Pathol. 1975;56:402–7.Google Scholar
  14. 14.
    Besedovsky H, Delrey A, Sorhim E, Dinarello CA. Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones. Science. 1986;233:652–4.PubMedCrossRefGoogle Scholar
  15. 15.
    Moraes FR, Garcia Leme J. Endogenous corticosteroids and insulin in acute inflammation. Microv Res. 1982;23:281–93.CrossRefGoogle Scholar
  16. 16.
    Garcia Leme J, Schapoval EES. Stimulation of the hypothalamo-pituitary-adrenal axis by compounds formed in inflamed tissues. Br J Pharmacol. 1975;53:75–82.Google Scholar

Copyright information

© Kluwer Acedemic Publishers 1992

Authors and Affiliations

  • A. J. De Brum-Fernandes
    • 1
  • V. De Falco
    • 1
  • F. A. Castro da Rocha
    • 1
  • S. Jancar
    • 2
  1. 1.Faculty of MedicineUniversity of São PauloBrazil
  2. 2.Department of Immunology, Institute of Biomedical SciencesUniversity of São PauloBrazil

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