, Volume 1, Issue 4, pp 289–294 | Cite as

Paradoxical effect of dexamethasone administration to rabbits with antigen-induced arthritis

  • A. J. De Brum-Fernandes
  • V. De Falco
  • F. A. Castro da Rocha
  • S. Jancar


Systemic dexamethasone phosphate administration to rabbits 2 h before induction of arthritis by antigen promoted a decrease in cellular influx, vascular permeability and eicosanoid concentrations in the synovial fluids. When administered 24 h before the articular challenge a significant increase in all parameters assessed was observed. A third group of animals receiving an injection of dexamethansone before the intra-articular challenge. The results suggest that a blockade of the hypothalamic-pituitary-adrenal axis could be responsible for the findings in animals treated 24 h before induction of arthritis, and that endogenous glucocorticoids can be important for the down-regulation, of the articular inflammatory reaction.


arthritis dexamethasone eicosanoids 


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Copyright information

© Kluwer Acedemic Publishers 1992

Authors and Affiliations

  • A. J. De Brum-Fernandes
    • 1
  • V. De Falco
    • 1
  • F. A. Castro da Rocha
    • 1
  • S. Jancar
    • 2
  1. 1.Faculty of MedicineUniversity of São PauloBrazil
  2. 2.Department of Immunology, Institute of Biomedical SciencesUniversity of São PauloBrazil

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