Skip to main content
SpringerLink
Log in

Endogenous vasopressin damages duodenal mucosa during haemorrhagic shock in rats

  • Cell Injury and Protection in the Gastrointestinal Tract: from Basic Science to Clinical Perspectives 8–11 October 1995, Pécs, Hungary
  • Published:
InflammoPharmacology Aims and scope Submit manuscript

Abstract

The role of endogenous vasopressin was studied in the development of mucosal erosions induced by haemorrhagic shock in the duodenum of the rat. Ischaemia-reperfusion provoked duodenal haemorrhagic lesions and elevated circulating and intramucosal vasopressin level. This mucosal injury was significantly attenuated by a vasopressin pressor receptor antagonist. Moreover, in the vasopressin-deficient Brattleboro homozygous rat, mucosal injury induced by haemorrhagic shock was also reduced. By contrast, when the vasopressin agonist, lysin-vasopressin, was administered, significant aggravation of ischaemia-reperfusion-induced duodenal mucosal injury was seen. These findings indicate the aggressive role of endogenous vasopressin, via its pressor receptors, in the generation of duodenal mucosal stress erosions in haemorrhagic shock.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Robert A, Kauffman GL. Stress ulcers, erosions, and gastric mucosal injury. In: Sleisenger MH, Fordtran JS, eds. Gastrointestinal Disease. Pathophysiology, Diagnosis, Management. Philadelphia: Saunders; 1989:772–92.

    Google Scholar 

  2. Ben-Manachem T, Fogel R, Patel RV. Profilaxis for stress-related gastric hemorrhage in the medical intensive care unit. Ann Intern Med. 1994;121:568–75.

    Google Scholar 

  3. St-Louis J, Schiffrin EL. Biological actions and binding sites for vasopressin on the mesenteric artery from normal and sodium depleted rats. Life Sci. 1984;35:1489–95.

    Article  PubMed  CAS  Google Scholar 

  4. Laszio F, Karacsony G, Pavo I, Varga CS, Rojik I, Laszio FA. Aggressive role of vasopressin in development of different gastric lesions in rats. Eur J Pharmacol. 1994;258:15–22.

    Article  Google Scholar 

  5. Hourani SMO, Cusack NJ. Pharmacological receptors on blood platelets. Pharmacol Rev. 1991;43:243–98.

    PubMed  CAS  Google Scholar 

  6. Siess W, Stiefel M, Binder H, Weber PC. Activation of V1-receptors by vasopressin stimulated inositol phospholipid hydrolysis and arachidonate metabolism in human platelets. Biochem J. 1986;233:83–91.

    PubMed  CAS  Google Scholar 

  7. Michell RH, Kirk CJ, Billah MM. Hormonal stimulation of phosphatidyl-inositol breakdown, with particular reference to the hepatic effect of vasopressin. Biochem Soc Trans. 1979;7:861–5.

    PubMed  CAS  Google Scholar 

  8. Laszlo FA, Laszlo F, de Wied D. Pharmacology and clinical perspectives of vasopressin antagonists. Pharmacol Rev. 1991;43:73–108.

    PubMed  CAS  Google Scholar 

  9. Manning M, Sawyer WH. Synthesis and receptor specificities of vasopressin antagonists. J Cardiovasc Pharmacol. 1986; Suppl 7:S29–35.

    Google Scholar 

  10. Laszlo F, Whittle BJR. Constitutive nitric oxide modulates the injurious actions of vasopression on rat intestinal microcirculation in acute endotoxaemia. Eur J Pharmacol. 1994;260:265–8.

    Article  PubMed  CAS  Google Scholar 

  11. Sokol HW, Valtin H, eds. The Brattleboro rat. Ann NY Acad Sci. 1982;394:1–828.

  12. Leung FW, Itoh H, Hirabayashi K, Guth PH. Role of blood flow in gastric and duodenal mucosal injury in the rat. Gastroenterology. 1985;88:281–9.

    PubMed  CAS  Google Scholar 

  13. Reichlin S. Neuroendocrinology. In: William RH, ed., Textbook of Endocrinology. Philadelphia: Saunders; 1985:492–511.

    Google Scholar 

  14. Melville RJ, Forsling ML, Frizis HI, LeQuesne LP. Stimulus of vasopressin release during elective intra-abdominal operations. Br J Surg. 1985;72:929–35.

    Article  Google Scholar 

  15. Robertson GL. Posterior pituitary. In Baxter JD, ed., Endocrinology and Metabolism. New York: McGraw-Hill; 1987:335–56.

    Google Scholar 

  16. Share L. Role of vasopressin in cardiovascular regulation. Physiol. Rev. 1988;68:1248–84.

    PubMed  CAS  Google Scholar 

  17. Liard JF, Deriaz P, Schelling P, Thibonnier M. Cardiac output distribution during vasopressin infusion or dehydration in conscious dogs. Am J Physiol. 1982;243:H663–9.

    PubMed  CAS  Google Scholar 

  18. Baker CH, Sutton ET, Zhou Z, Deitz JR. Microvascular vasopressin effects during endotoxin shock in the rat. Circ Shock. 1990;30:81–95.

    PubMed  CAS  Google Scholar 

  19. Vanner S, Jiang M-M, Brooks VL, Surprenant A. Characterization of vasopressin actions in isolat submucosal arterioles of the intestinal microcirculation. Circ Res. 1990;67:1017–26.

    PubMed  CAS  Google Scholar 

  20. McNeill JR, Stark RD, Greenway CV. Intestinal vasoconstriction after hemorrhage: role of vasopressin and angiotensin. Am J Physiol. 1970;219:1342–7.

    PubMed  CAS  Google Scholar 

  21. Stark RD, McNeill JR, Greenway CV. Sympathetic and hypophyseal roles in the splenic response to hemorrhage. Am J Physiol 1970;22:837–40.

    Google Scholar 

  22. Filep J, Rosenkrantz B. Mechanism of vasopressin-induced platelet aggregation. Thromb Res. 1987;45:7–16.

    Article  PubMed  CAS  Google Scholar 

  23. Nadasy GL, Szekacs B, Juhasz I, Monos E. Pharmacological modulation of prostacyclin and thromboxane production of rat and cat venous tissue slices. Prostaglandins. 1992;44:339–55.

    Article  PubMed  CAS  Google Scholar 

  24. Rosenbar GA, Kyner WT, Fenstermacher JD, Patlak CS. Effect of vasopressin on ependymal and capillary permeability to tritiated water in cat. Am J Physiol. 1986;251:F485–9.

    Google Scholar 

  25. Doczi T, Szerdahelyi P, Gulya K, Kiss J. Brain water accumulation after the central administration of vasopressin. Neurosurgery. 1982;11:402–6.

    Article  PubMed  CAS  Google Scholar 

  26. Laszlo F, Karacsony G, Szabo E, Lang J, Balaspiri L, Laszlo FA. The role of vasopressin in the pathogenesis of ethanol-induced gastric hemorrhagic erosions in rats. Gastroenterology. 1991;101: 1242–8.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. First Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary

    F. László, Z. Szepes & G. Karácsony

  2. Department of Comparative Physiology, Attila József University of Sciences, Szeged, Hungary

    C. S. Varga & F. A. László

Authors
  1. F. László
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Z. Szepes
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. G. Karácsony
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. C. S. Varga
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. F. A. László
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

László, F., Szepes, Z., Karácsony, G. et al. Endogenous vasopressin damages duodenal mucosa during haemorrhagic shock in rats. Inflammopharmacology 4, 379–385 (1996). https://doi.org/10.1007/BF02755790

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02755790

Keywords

Search

Navigation