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InflammoPharmacology

, Volume 4, Issue 4, pp 341–349 | Cite as

Inhibition of rabbit gastric epithelial restoration by a water extract ofHelicobacter pylori: evidence using a cultured cell model

  • N. Sato
  • S. Watanabe
  • X-E. Wang
  • M. Hirose
  • H. Oide
  • T. Kitamura
  • R. Ohkura
  • K. Otaka
  • H. Miwa
  • A. Miyazaki
  • M. Aihara
  • A. Azuma
  • K. Imagawa
  • M. Kikuchi
Cell Injury and Protection in the Gastrointestinal Tract: from Basic Science to Clinical Perspectives 8–11 October 1995, Pécs, Hungary
  • 14 Downloads

Abstract

The detailed mechanism ofH. pylori-induced gastric damage is still unknown. In this study, we showed that a water extract ofH. pylori retarded the epithelial restoration in a cultured rabbit gastric epithelial cell model with the inhibition of both cell migration and proliferation. Although this inhibitory substance has not yet been biochemically characterized, it is different from knownH. pylori associate-cytotoxins and ammonia. From these results, we hypothesize that these bacteria, directly play a role in disturbance of peptic ulcer healing in vivo.

Keywords

gastric epithelial cell restoration restitution Helicobacter pylori cytotoxin peptic ulcer 

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Copyright information

© Birkhäuser Verlag AG 1996

Authors and Affiliations

  • N. Sato
    • 1
  • S. Watanabe
    • 1
  • X-E. Wang
    • 1
  • M. Hirose
    • 1
  • H. Oide
    • 1
  • T. Kitamura
    • 1
  • R. Ohkura
    • 1
  • K. Otaka
    • 1
  • H. Miwa
    • 1
  • A. Miyazaki
    • 1
  • M. Aihara
    • 2
  • A. Azuma
    • 2
  • K. Imagawa
    • 2
  • M. Kikuchi
    • 2
  1. 1.Department of GastroenterologyJuntendo University School of MedicineTokyo
  2. 2.Microbiological Research InstituteOtsuka Pharmaceutical Co. Ltd.TokushimaJapan

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