Immunology of malaria
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Infection with parasites and exposure to their complex antigens, generates a diverse immune response. The levels of antibody activity or cellular sensitization may be measured using a variety of immunological tests but these provide little or no correlation with the degree of protective immunity that the host may possess. Acquired immunity depends upon specific inhibitory antibody as well as imprecisely defined cell-mediated and non-specific mechanisms. Survival of parasites is promoted by their capacity for antigenic variation and their intracellular location and by processes which may interfere with host immunity including production of lymphocyte mitogens and soluble antigens and generation of immunosuppressor cells.
Key wordsMalaria immunity humoral cellular
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