Effect of acetazolamide on salivary excretion of inorganic ions in sheep

  • A. V. Chalyshev
Comparative and Ontogenic Physiology


The salivary excretion of inorganic ions in sheep was studied parallel with infusion of salt solutions of different composition through the temporary isolated rumen cavityin vivo. The amount of Na+ excreted with saliva decreases by 15–55% after an intravenous loading with acetazolamide (50 mg/kg of animal weight) and by 25–55%, of K+, which represents a part of the ion excretion with participation of H+ exchanges. The Na+ excretion that is not inhibited by acetazolamide in sheep is about 40 mmol/10 kg of exchange mass per 1 h in all experiments with loading.


Salivary Gland Acinar Cell Acetazolamide Evolutionary Biochemistry Salivary Secretion 
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© MAIK “Nauk/Interperiodica” 2000

Authors and Affiliations

  • A. V. Chalyshev
    • 1
  1. 1.Institute of Physiology, Komi Research CenterUral Branch of the Russian Academy of SciencesSyktyvkarRussia

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