The Indian Journal of Pediatrics

, Volume 60, Issue 4, pp 539–549 | Cite as

Bone marrow transplantation

  • T. S. Vats
Symposium: Hematology/Oncology—II


Bone marrow transplantations have a definite role in treatment of leukemias and lymphomas. In acute myeloid leukemia and CML an allogeneic transplant using an HLA identical donor certainly provides a far superior survival than chemotherapy. Patients with Ph’ chromosome need to be transplanted in first remission if a suitable donor is available. In recurrent lymphomas the best results are chieved if the patient is transplanted in complete remission. Transplantation done using minor mismatched family donors or unrelated donors are still considered experimental and more data is needed before final recomendations can be made. Availability of supportive services is an absolute must prior to establishing transplant program. Selection of patients for transplantation should be done after carefully reviewing the indications and discussing with the family the emotional, financial and physical burden of the procedure. For selected indications in leukemias and lymphomas, BMT may be the only viable treatment option and therefore must be considered.


Acute Lymphoblastic Leukemia Bone Marrow Transplantation Chronic Myeloid Leukemia BCNU Autologous Bone Marrow Transplantation 
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  1. 1.
    Yeager AN. Bone marrow transplantation in children.Pediatr Ann 1988;17:694–713.PubMedGoogle Scholar
  2. 2.
    Santos GW, Sensenbrenner LL, Burke PJ et al. Marrow transplantation in man following cyclophosphamide.Transplant Proc 1971;3:400–404.PubMedGoogle Scholar
  3. 3.
    Thomas ED. Marrow transplantation for malignant disease (Kamofsky Memorial Lecture).J Clin Oncol 1983;1:517–531.PubMedGoogle Scholar
  4. 4.
    Willams TE, Safarimaryakis S. In: Leonard E, Pochedly C, ed.Bone Marrow Transplantation in Children. New York: Raven Press, 1990:221–242.Google Scholar
  5. 5.
    Hows JM, Yin JL, Marsh et al. Histocompatible unrelated volunteer donors compared with HLA nonidentical family donors in marrow transplantation for aplastic anemia and leukemia.Blood 1986;68:1322–1328.PubMedGoogle Scholar
  6. 6.
    Braine HG, Sensenbrenner LL, Wright SK et al. Bone marrow transplantation with major ABO blood group incompatibility using erythrocyte depletion of marrow prior to infusion.Blood 1982;60:420–425.PubMedGoogle Scholar
  7. 7.
    Sullivan KM, Parkman R. The pathophysiology and treatment of graft-versus-host disease.Clin Haematol 1983;12:775–789.PubMedGoogle Scholar
  8. 8.
    Sullivan KM, Shulman HM, Storb R et al. Chronic graft-versus-host disease in 52 patients: adverse natural course and successful treatment with combination immunosuppression.Blood 1981;57:267–276.PubMedGoogle Scholar
  9. 9.
    Quinn JJ. Bone marrow transplantation in management of childhood cancer.Pediatr Clin North Am 1985;32:811–833.PubMedGoogle Scholar
  10. 10.
    Weiden PL, Sullivan KM, Flournoy N et al. Antileukemic effect of graft versus host disease contribution to improved survival after allogeneic marrow transplantation.N Engl J Med 1981;304:1529–1533.PubMedCrossRefGoogle Scholar
  11. 11.
    Hams R, Neudort S, McGill M CMV-negative blood products for prevention of cytomegaloviral pneumonia in seronegativ transplant recipients.J Cell Biochem 1986; 10 (Suppl D):242.Google Scholar
  12. 12.
    Meyers JD, Flournoy N, Wade JC et al. Biology of interstitial pneumonia after bone marrow transplantation. In: Gale RP, ed.Recent Advances in Bone Marrow Transplantation. New York: Alan R. Liss, Inc. 1983.Google Scholar
  13. 13.
    Storb R, Santos GW. Application of bone marrow transplantation in leukemia and aplastic anaemia.Clin Haematol 1983;127:721–737Google Scholar
  14. 14.
    Wood WG, Dehner LP, Nesbit ME et al. Fatal veno-occlusive disease of the liver following high dose chemotherapy, irradiation and bone marrow transplantation.Am J Med 1980;68:258–290.Google Scholar
  15. 15.
    Triggs ME. Bone marrow transplantation for treatment of leukemia in children.Pediatr Clin North Am 1988;35:933–948.Google Scholar
  16. 16.
    Weidorf SA, Lysne J, Wind D et al. Positive effect of phosphylatic total parenteral nutrition on long term outcome of bone marrow transplantation.Transplantation 1987; 43:833–838.CrossRefGoogle Scholar
  17. 17.
    Lum LG. The kinetics of immune reconstitution after human marrow transplantation.Blood 1987;69:369–390.PubMedGoogle Scholar
  18. 18.
    Phillips GL, Herzig RH, Lazarus HM et al. High-dose chemotherapy, fractionated total body irradiation and allogeneic marrow transplantation for malignant lymphoma.J Clin Oncol 1986;4(4):480–488.PubMedGoogle Scholar
  19. 19.
    Appelbaum FR, Sullivan KM, Thomas ED et al. Allogeneic marrow transplantation in the treatment of MOPP-resistant Hodgkin's disease.J Clin Oncol 1985;3(11):1490–1494.PubMedGoogle Scholar
  20. 20.
    Philip T, Dumont J, Teillet F et al. High-dose chemotherapy and autologous bone marrow transplantation in refractory Hodgkin's disease.Br J Cancer 1986;53: 737–742.PubMedGoogle Scholar
  21. 21.
    O'Leary M, Ramsay NKC, Nesbit ME et al. Bone marrow transplantation for non-Hodgkin's lymphoma in children and young adults.Am J Med 1983;74(3):497–501.PubMedCrossRefGoogle Scholar
  22. 22.
    Appelbaum FR, Deisseroth AB, Graw RG et al. Prolonged complete remission following high-dose chemotherapy of Burkitt's lymphoma in release.Cancer 1978;41:1059–1063.PubMedCrossRefGoogle Scholar
  23. 23.
    Hartman O, Pein F, Beaujean F et al. High-dose polychemotherapy with autologous bone marrow transplantation in children with relapsed non-Hodgkin's lymphoma.J Clin Oncol 1984;2:979–985.Google Scholar
  24. 24.
    Mascret B, Maraninchi D, Gastaut JA et al. Treatment of malignant lymphoma with high dose of chemo or chemoradiotherapy and bone marrow transplantation.Eur J Cancer 1986;22(4):461–471.CrossRefGoogle Scholar
  25. 25.
    Johnson FL, Thomas ED, Clark BS et al. A comparison of marrow transplantation with chemotherapy for children with acute lymphoblastic leukemia in second or subsequent remission.N Engl J Med 1981;305:846–851.PubMedCrossRefGoogle Scholar
  26. 26.
    Woods WG, Nesbit ME, Ramsay NKC et al. Intensive therapy followed by bone marrow transplantation for patients with acute lymphocytic leukemia in second or subsequent remission. Determination of prognostic factor.Blood 1983;61:1182–1189.PubMedGoogle Scholar
  27. 27.
    Chessels JM, Leiper AD, Plowman PN et al. Bone marrow transplantation has a limited role in prolonging second marrow remission in childhood lymphoblastic leukemia.Lancet 1986;1239–1241.Google Scholar
  28. 28.
    Rivera GK, Buchanan G, Boyett JM et al. Intensive retreatment of childhood acute lymphoblastic leukemia in first bone marrow replase.N Engl J Med 1986;315:273–278.PubMedCrossRefGoogle Scholar
  29. 29.
    Coccia P, Strandjord S, Warkentine P et al. High-dose cytosine arabinoside and fractionated total body irradiation: An improved preparative regimen for bone marrow transplantation of children with acute lymphoblastic leukemia in remission.Blood 1988;71:888–893.PubMedGoogle Scholar
  30. 30.
    Ramsay N, LeBien T, Nesbit M et al. Autologous bone marrow transplantation for patients with acute lymphoblastic leukemia in second or subsequent remission: results of bone marrow treatment with monoclonal antibodies BA-1, BA-2 and BA-3 plus complement.Blood 1985;66:508–513.PubMedGoogle Scholar
  31. 31.
    Kaizer H, Stuart RK, Brookmeyer R et al. Autologous bone marrow transplantation in acute leukemia: a phase II study of in vitro treatment with 4-hydroperoxycyclophosphamide to purge tumor cells.Blood 1985;65:1504–1510.PubMedGoogle Scholar
  32. 32.
    Thomas ED, Buckner CD, Clift RA et al. Marrow transplantation for acute nonlymphoblastic leukemia in first remission.N Engl J Med 1979;301:597–599.PubMedCrossRefGoogle Scholar
  33. 33.
    Weinstein HJ, Mayer RJ, Rosenthal D et al. Chemotherapy for acute myelogenous leukemia in children and adults: VAPA update.Blood 1983;62:315–319.PubMedGoogle Scholar
  34. 34.
    Nesbit M, Buckley J, Lampkin B et al. Comparison of allogeneic bone marrow transplantation (BMT) with maintenance chemotherapy in previously untreated childhood acute nonlymphocytic leukemia (ANLL).Proc. Amer Soc Clin Oncol 1987;6: 163 (abst. 640).Google Scholar
  35. 35.
    Applebaum FR, Clift RA, Badner CD et al. Allogeneic marrow transplantation for acute nonlymphoblastic leukemia after first relapse.Blood 1983;61:949–953.Google Scholar
  36. 36.
    Yeager AM, Kaiser H, Santos G et al. Autologous bone marrow transplantation in patients with acute nonlymphocytic leukemia, using ex vivo marrow treated with 4-hydroperoxycyclophosphamide.N Engl J Med 1986;315:141–147.PubMedCrossRefGoogle Scholar
  37. 37.
    Castro-Malaspina H, Schaison G, Briere J et al. Philadelphia chromosome-positive chronic myelocytic leukemia in children (survival and prognostic factor).Cancer 1983;52:721–727.PubMedCrossRefGoogle Scholar
  38. 38.
    Goldman JM, Apperley JF, Jones L et al. Bone marrow transplantation for patients with chronic myeloid leukemia.N Engl J Med 1986;314:202–207.PubMedCrossRefGoogle Scholar
  39. 39.
    Sanders J, Buckner D, Thomas E et al. Allogeneic marrow transplantation for children with juvenile chronic myelogenous leukemia.Blood 1988;71:1144–1146.PubMedGoogle Scholar
  40. 40.
    Guinan E, Tarbell N, Tantravahi R et al. Bone marrow transplantation for children with myelodysplastic syndromes.Blood 1989;73:619–622.PubMedGoogle Scholar
  41. 41.
    Gingrich R, Howe C, Goekin N et al. Successful bone marrow transplantation with partially matched unrelated donors.Transplantation Proceedings 1985;17:450–452.Google Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 1993

Authors and Affiliations

  • T. S. Vats
    • 1
  1. 1.Pediatric Hematology/OncologyUniversity of Kansas Medical CenterKansas CityU.S.A.

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