Serum levels of gentamicin at peak and trough in neonates and infants
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The peak and the trough levels of serum gentamicin were determined in 50 cases of neonates and infants by microbiological assay method. The peak levels in the neonates and the infants were 5.98±0.48 and 4.63±0.31 mcg/ml respectively. The trough levels in the corresponding group were 1.06±0.19 and 0.94±0.23 mcg/ml. The mean values of the peak and trough levels of the antibiotic were 5.57 and 1.02 mcg/ml respectively. It was observed that there was a significant lower peak concentration in the infants than in the neonates. A significantly higher peak concentration of gentamicin was observed in babies aged under 7 days than in those above 7 days. The route of administration (between I/M and I/V) did not seem to have any effect on the peak and trough levels of the antibiotics.
Key WordsGenatamicin Peak and Trough Levels Neonatal Sepsis
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- 1.Eriksson M. Neonatal Septicemia.Acta Pediatr Scand 1983; 72: 1–8.Google Scholar
- 2.Finitzo-Hieter T, George H, McCracken Jr et al. Ototoxicity in neonates treated with gentamicin and kanamycin: Results of a four-year controlled follow-up study.Pediatrics 1979; 63: 443–449.Google Scholar
- 4.McCraken GH, Jones LG. Gentamicin in the neonatal period.Am J Dis Child 1970; 120: 524–533.Google Scholar
- 5.McCracken GH, Chrane DF, Thomas ML. Pharmacologic evaluation of gentamicin in newborn infants.J Infect Dis 1971; 124 (suppl): 214–223.Google Scholar
- 8.Dobbs SM, Mawer GE. Intravenous injection of gentamicin and tobramycin without impairment of hearing.J Infect Dis 1976; 134: S112-S114.Google Scholar
- 14.Hewitt WL. Reflections on the clinical pharmacology of gentamicin.Acta Pathol Microbiol Scan 1973; B 81: 151–156.Google Scholar
- 16.Jackson GG, Arcieri G. Ototoxicity of gentamicin in man: a survey and controlled analysis of clinical experience in the United States.J Infect Dis 1969; 119: 410–416.Google Scholar
- 22.John W, Paisley MD, Anrnold L et al. Gentamicin in newborn infants.Am J Dis Child 1973; 126: 473–477.Google Scholar