The Indian Journal of Pediatrics

, Volume 58, Issue 2, pp 217–221 | Cite as

Serum levels of gentamicin at peak and trough in neonates and infants

  • Mohammod Shahidullah
  • M. Q. Talukder
  • A. K. Azad Chowdhury
  • Shawkat Ali
  • Abdur Rashid
Original Articles


The peak and the trough levels of serum gentamicin were determined in 50 cases of neonates and infants by microbiological assay method. The peak levels in the neonates and the infants were 5.98±0.48 and 4.63±0.31 mcg/ml respectively. The trough levels in the corresponding group were 1.06±0.19 and 0.94±0.23 mcg/ml. The mean values of the peak and trough levels of the antibiotic were 5.57 and 1.02 mcg/ml respectively. It was observed that there was a significant lower peak concentration in the infants than in the neonates. A significantly higher peak concentration of gentamicin was observed in babies aged under 7 days than in those above 7 days. The route of administration (between I/M and I/V) did not seem to have any effect on the peak and trough levels of the antibiotics.

Key Words

Genatamicin Peak and Trough Levels Neonatal Sepsis 


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Copyright information

© Indian Academy of Sciences 1991

Authors and Affiliations

  • Mohammod Shahidullah
    • 1
  • M. Q. Talukder
    • 2
  • A. K. Azad Chowdhury
    • 3
  • Shawkat Ali
    • 4
  • Abdur Rashid
    • 2
  1. 1.Department of Child HealthIPGMRDhaka
  2. 2.Division of Gastroenterology and NutritionIPGMRDhaka
  3. 3.Department of PharmacyDhaka UniversityDhaka
  4. 4.Department of BiochemistryDhaka UniversityDhaka

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