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The Indian Journal of Pediatrics

, Volume 53, Issue 2, pp 179–198 | Cite as

Antituberculous therapy in children

  • Vimlesh Seth
Symposium: Pediatric Pharmacology—II

Abstract

The advent of effective chemotherapeutic agents for the treatment of tuberculosis necessitates parallel emphasis in designing various short-course chemotherapy regimens in treating tuberculosis in children. Direct extrapolation from studies in adults is not appropriate because of differing pharmacokinetics and adverse drug reactions of antituberculous drugs in children. The pharmacological basis of antituberculous drugs and guidelines for using various drug regimens in relation to the varied clinical profile of tuberculosis in children have been discussed. It has been observed that the commonest type of tuberculosis in children is the pulmonary primary complex (71·4%), followed, by, progressive, primary disease (71·4%). Pleural effusion, bronchopneumonia and miliary tuberculosis are much less frequent. The 3 drug regimen does not seem to offer any advantage over the two drug regimen in the treatment of the primary pulmonary complex, as assessed by radiological clearance. Compliance is poorer in long-term and intermittent therapy as compared to short-course, continuous therapy.

Keywords

Tuberculosis Rifampicin Isoniazid Pulmonary Tuberculosis Ethambutol 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Dr. K C Chaudhuri Foundation 1986

Authors and Affiliations

  • Vimlesh Seth
    • 1
  1. 1.Department of PediatricsAll India Institute of Medical SciencesNew Delhi

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