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Antituberculous therapy in children

  • Symposium: Pediatric Pharmacology—II
  • Published:
The Indian Journal of Pediatrics Aims and scope Submit manuscript

An Erratum to this article was published on 01 May 1986

Abstract

The advent of effective chemotherapeutic agents for the treatment of tuberculosis necessitates parallel emphasis in designing various short-course chemotherapy regimens in treating tuberculosis in children. Direct extrapolation from studies in adults is not appropriate because of differing pharmacokinetics and adverse drug reactions of antituberculous drugs in children. The pharmacological basis of antituberculous drugs and guidelines for using various drug regimens in relation to the varied clinical profile of tuberculosis in children have been discussed. It has been observed that the commonest type of tuberculosis in children is the pulmonary primary complex (71·4%), followed, by, progressive, primary disease (71·4%). Pleural effusion, bronchopneumonia and miliary tuberculosis are much less frequent. The 3 drug regimen does not seem to offer any advantage over the two drug regimen in the treatment of the primary pulmonary complex, as assessed by radiological clearance. Compliance is poorer in long-term and intermittent therapy as compared to short-course, continuous therapy.

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Authors and Affiliations

  1. Department of Pediatrics, All India Institute of Medical Sciences, 110029, New Delhi

    Vimlesh Seth (Associate Professor)

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  1. Vimlesh Seth
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An erratum to this article is available at http://dx.doi.org/10.1007/BF02760435.

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Seth, V. Antituberculous therapy in children. Indian J Pediatr 53, 179–198 (1986). https://doi.org/10.1007/BF02748507

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