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Strahlentherapie und Onkologie

, Volume 175, Issue 1, pp 1–9 | Cite as

Blood flow and oxygenation status of human tumors

Clinical investigations
  • Horst J. Feldmann
  • Michael Molls
  • Peter Vaupel
Aktuelles Forum

Abstract

Purpose

There is a large body of evidence suggesting that blood flow and oxygenation of human tumors are important research topics which may explain, in particular, resistance to radiation and to many antineoplastic drugs, which can limit the curability of solid tumors by radiotherapy and chemotherapy.

Materials and Methods

This manuscirpt reviews the clinical investigations which have been performed regarding blood flow and oxygenation status of human tumors in radiation oncology.

Results

The possible uses and limitations of the prognostic significance and the changes under therapy measuring blood flow and oxygenation in human tumors were discussed. In addition, several aproaches were summarized, which can improve the microvascular O2 availability and perfusion-limited O2 delivery.

Conclusion

The clinical data concerning the prognostic significance of blood flow, vascular function and oxygenation of human tumors are relevant for patient selection in clinical oncology. Strategies to improve traditional cancer therapy by modulation of the oxygenation status remain quite promising but more critical research and sophisticated clinical studies are necessary before its true potential is known.

Key Words

Blood perfusion Oxygenation of human tumors Prognostic significance Modulation of tumor oxygenation 

Durchblutungs- und Oxygenierungsstatus von Tumoren beim Menschen — Klinische Untersuchungen

Zusammenfassung

Hintergrund

Das Tumormikromilieu ist ein wesentlicher Faktor, der das Ansprechen von Tumoren auf konservative Behandlungsverfahren und damit die Heilungschancen gegenüber Strahlen- und/oder Chemotherapie bestimmt.

Material und Methoden

Die folgende übersicht greift die wichtigsten Parameter des Mikromilieus, die in der klinischen Strahlentherapie untersucht wurden, auf: die Tumorvaskularisierung, Tumordurchblutung und die Oxygenierung solider Tumoren.

Ergebnisse

Die klinischen Messungen zur Durchblutung und Tumoroxygenierung werden prätherapeutisch sowie im Verlauf unter Strahlentherapie zusammenfassend dargestellt und ihre prognostische Wertigkeit diskutiert. Darüber hinaus wird auf klinische Versuche eingegangen, die zu einer Verbesserung des intravaskulÄren Sauerstoffgehalts sowie einer Verbesserung der Mikrozirkulation führen und damit die diffusions- und perfusionslimitierte Sauerstoffverfügbarkeit überwinden können.

Schlu\folgerung

Die klinischen Ergebnisse zur prognostischen Bedeutung von Tumordurchblutung und Oxygenierung werden zukünftig für die Selektion von Patienten und die Individualisierung der Tumortherapie von Bedeutung sein. Ansätze, die Therapieergebnisse konventioneller Verfahren durch Beeinflussung der Tumoroxygenierung zu verbessern, sind vielversprechend, müssen allerdings im Rahmen systematischer klinischer Studien geprüft werden.

Schlüsselwörter

Durchblutung Tumoroxygenierung Prognostische Wertigkeit Beeinflussung der Oxygenierung 

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Copyright information

© Urban & Vogel 1999

Authors and Affiliations

  • Horst J. Feldmann
    • 1
  • Michael Molls
    • 1
  • Peter Vaupel
    • 2
  1. 1.Klinik und Poliklinik für Strahlentherapie und Radiologische OnkologieKlinikum rechts der Isar der Technischen UniversitätMünchen
  2. 2.Institut für Physiologie und Pathophysiologie der Universität MainzGermany

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