Primitive neuroectodermal tumor of the meninges: An histological, immunohistochemical, ultrastructural, and cytogenetic study
- 57 Downloads
We report a case of primitive neuroectodermal tumor (PNET) arising from the meninges in a 30-yr-old female patient whose clinical and radiological features were consistent with meningioma.
The neoplasm was composed of primitive small, round cells, growing in sheets and nests in continuity with meningeal layers. Ultrastructurally, the neoplastic cells were characterized by large and regular nuclei, primitive cytoplasm with pools of glycogen, and lack of dense core granules. The neuroectodermal nature of the tumor was confirmed by positive immunostaining for vimentin, neurofilaments, neuron specific enolase (NSE), and 013 (an antibody raised against MIC2 antigen). Further support to the diagnosis was obtained by reverse transcriptase-polymerase chain reaction (RT-PCR) detection of Chromogranin A and Secretogranin II genes. t(11;22) translocation was also observed by RT-PCR, a finding that was not recorded in previously described intracranial PNET. The tumor followed a malignant course, recurring and spreading to chest wall and sacro-iliac region over a 10-yr period. The meningeal location enlarges the topographic spectrum of intracranial PNET, and this tumor has to be considered in the differential diagnosis with meningioma.
Key WordsPrimitive neuroectodermal tumors meninges RT-PCR Chromogranin A Secretogranin II t(11:22) translocation
Unable to display preview. Download preview PDF.
- 1.Duckett S. Pediatric neuropathology. Baltimore, MD: Williams and Wilkins, 1995.Google Scholar
- 3.Enzinger FM, Weiss SW. Soft tissues tumors. 3rd ed. St. Louis: Mosby, 1995.Google Scholar
- 5.Rosai J. Ackerman’s surgical pathology. 8th ed. St. Louis: Mosby, 1996.Google Scholar
- 9.Pagani A, Macri’ L, Rosolen A, Toffolatti L, Stella A, Bussolati G. Neuroendocrine differentiation in Ewing’s sarcomas and primitive neuroectodermal tumors revealed by reverse transcriptase-polymerase chain reaction of chromogranins’ mRNA. Diagn Mol Pathol 1988, in press.Google Scholar
- 12.Krishan VV, Saraswathy A, Misra BK, Rout D. Primary Ewing’s sarcoma of the base of skull: a case report. Indian J Pathol Microbiol 36:477–479, 1993.Google Scholar
- 13.Brinkhuis M, Wjinaendts LCD, van der Linden JC, van Unnik AJM, Voute PA, Baak JPA, Meijer CJLM. Peripheral primitive neuroectodermal tumor and extraosseous Ewing’s sarcoma; a histological, immunohistochemical and DNA flow cytometric study. Virch Arch 425:611–616, 1995.Google Scholar
- 14.Ambros IM, Ambros PF, Strehl S, Kovar H, Gadner H, Salzer-Kuntschik M. MIC2 is a specific marker for Ewing’s sarcoma and peripheral primitive neuroectodermal tumors: evidence for a common histogenesis of Ewing’s and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration. Cancer 67:1886–1893, 1991.PubMedCrossRefGoogle Scholar