Endocrine Pathology

, Volume 9, Issue 1, pp 71–78 | Cite as

Lymphocytic hypophysitis: Light and electron microscopic findings and correlation to clinical appearance

  • Marita Fehn
  • Clemens Sommer
  • Dieter K. Lüdecke
  • Ursula Plöckinger
  • Wolfgang Saeger
Clinical Research


Light and electron microscopic findings of six cases of lymphocytic hypophysitis of a collective of 2500 surgical specimens are presented. Five cases were obtained by surgery, one case was obtained from autopsy. Light microscopy revealed an infiltration of mature lymphocytes and plasma cells in the interstitium, partly in the acini, as well as in the posterior lobe and the capsule. The structure of the remaining anterior lobe was normal. The final stage of lymphocytic hypophysitis is fibrosis, which was seen in all cases to varying degrees. The infiltrate consisted mainly of T-lymphocytes, being positive for CK 45 RO and CD 43. Immunocytochemical staining revealed different proportions of residual adenohypophyseal cells. Mainly prolactin reactive cells were observed as were growth hormone reactive cells. By electron microscopy some ruptured acini and damaged adenohypophyseal cells could be seen. Few pituitary cells contained enlarged lysosomal bodies or oncocytic changes. Inflammation causing enlargement of the pituitary leads to patients often being operated under the preoperative diagnosis of a tumor of the sellar region. It is important to identify this special type of hypophysitis, as a different course of treatment is required.

Key Words

Lymphocytic hypophysitis pituitary tumor morphology immunocytochemistry electron microscopy 


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Copyright information

© Humana Press Inc 1998

Authors and Affiliations

  • Marita Fehn
    • 1
  • Clemens Sommer
    • 4
  • Dieter K. Lüdecke
    • 2
  • Ursula Plöckinger
    • 3
  • Wolfgang Saeger
    • 1
  1. 1.Institute of Pathology of the MarienkrankenhausHamburgGermany
  2. 2.Clinic of NeurosurgeryUniversity Hospital EppendorfHamburgGermany
  3. 3.Clinic Benjamin FranklinFree University of Berlin, Department of EndocrinologyBerlinGermany
  4. 4.Institute of NeuropathologyUniversity of HeidelbergHeidelbergGermany

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