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Chinese Journal of Clinical Oncology

, Volume 1, Issue 1, pp 71–74 | Cite as

Pulmonary atypical adenomatous hyperplasia and bronchioloalveolar carcinoma

  • Meilin Xu
  • Xia Yang
  • Zhiyao Zhang
Orginal Article

Abstract

Objective

To study the relationship between atypical adenomatous hyperplasia (AAH) and bronchioloalveolar carcinoma (BAC).

Methods

Morphometric, immunohistochemical and ultrastructural analyses were performed in 4 patients with low grade AAH, 5 with high grade AAH and 7 with BAC.

Results

The mean nuclear areas of high grade AAH and BAC were greater than those of low grade AAH (P<0.05); p53 protein expression was negative in 4 cases of low grade AAH,while the positive rates in high grade AAH and BAC were 40% (2/5) and 57% (4/7), respectively.

Conclusiion

The development of BAC is stepwise. AAH appears to be a lesion closely related with BAC, probably as its genuine precursor.

Keywords

lung atypical adenomatous hyperplasia bronchioloalveola lungcarcinoma p53 protein electron microscopy 

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Copyright information

© Chinese Anti-Cancer Association and Springer 2003

Authors and Affiliations

  • Meilin Xu
    • 1
  • Xia Yang
    • 1
  • Zhiyao Zhang
    • 1
  1. 1.Department of PathologyTianjin Chest HospitalTianjinChina

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