HBME-1, CD15 and p53 protein expression in thyroid carcinoma and their significance in diagnosis
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To investigate the protein expression of HBME-1, CD15 and p53 in thyroid carcinoma and in bengin thyroid diseases and to evaluate their value in diagnosis of thyroid disease.
Sixty-one cases of thyroid carcinoma and 27 cases of different kinds of benign thyroid diseases were studied by immunohistochemical methods.
All cases of differentiated thyroid carcinoma were positive for HBME-1, 35.7% positive for CD15 and only 14.3% positive for p53. Twenty-seven cases of benign thyroid lesions were absolutely negative for p53, 7.4% of which were CD15 positive and 25.9% of which were HBME-1 positive.
HBME-1 and CD15 may be helpful to assist differential diagnosis of thyroid carcinoma from benign thyroid diseases.
Keywordsthyroid carcinoma HBME-1 CD15 p53 immunohistochemistry diagnosis
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