Correlative study on MRI morphologic features, pathology, and molecular biology of breast cancer
To investigate the correlation among MRI morphologic features, pathology, and molecular biology of breast cancer.
MRI was used to analyze the morphologic features of breast cancers of 78 patients before operation. The mastectomy specimens of the breast neoplasms were immunohistochemically stained, and the expression of the estrogen (ER), progesterone receptor (PR), C—erbB—2, P53, and the distribution of microvessel density (MVD) measured. The pathologic results were compared with the MRI features.
Among the 80 breast cancers, ER positive expression was positively correlated with the spicular contour of breast cancers (P<0.01 ), while showing a significant inverse correlation with the T—stage (P<0.05). C—erbB —2 and P53 positive expression were positively correlated with the necrotic center of the cancers (P<0.05). The expression of. PR was not significantly correlated with the spicular contour, obscure margin, necrotic center, and T—stage of these cancers (P>0.05). Among 41 breast cancers examined with dynamic contrast enhanced MR, there was a positive correlation between the spatial distribution of the contrast agent and MVD (P<0.01).
To a certain extent there is some correlation among the MRI morphologic features, pathology, and molecular biological factors in breast cancer. The biological behavior and prognosis of breast cancer can be assessed based on MRI features.
Keywordsbreast neoplasm magnetic resonance imaging pathology molecular biology
- 1.Pan P, Liu AL, Song QW, et al. Correlation of MR imaging characterizations and histologic microvessel density in hepatocellular carcinoma. Chin J Radiol. 2002; 36:420–424.Google Scholar
- 2.Peng XB, Lin YQ, Luo YH, et al. The correlation between CT appearance and the structure and abnormal expression of P53 gene in peripheral lung cancer. Chin J Med Imaging. 2000; 8:210–212.Google Scholar
- 3.Liu JK, Zeng. JZH, Zhou JH. Study on the correlation between CT appearance and DNA conients in peripheral lung adenocarcinomas and squamous —cell carcinomas. Chin J Radiol. 1996; 30:15–19.Google Scholar
- 5.Fizgibbons PL, Page DL, Weaver D, et al. Prognostic factors in breast cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med. 2000; 124:966–978.Google Scholar
- 11.Liu PF, Bao RX, Niu Y, et al. Angiogenesis and dynamic contrast enhanced MRI of benign and malignant breast lesions: preliminary results. Chin J Radiol. 2002; 36:967–972.Google Scholar