Endocrine Pathology

, Volume 9, Issue 4, pp 375–377 | Cite as

Thirty-year survival with an untreated malignant duodenal somatostatinoma

  • Jan Ulfberg
  • Tibor Tot
  • Erik Wilander
Case Report


Gastrointestinal somatostatinomas are rare. Only 56 cases with duodenal origin have been reported in the literature. The long-term course of an untreated tumor like this is unknown.

We report a case of a male patient who lived 30 yr with an untreated metastatic duodenal somatostatinoma. This case suggests that a duodenal somatostatinoma may be of low malignant potential and that expectancy when treating this tumor might be indicated.

Key Words



Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ganda OP, Weir GC, Soeldner JS, Legg MA, Chick WI, Patel YC. “Somatostatinoma”: A somatostatin-containing tumor of the endocrine pancreas. N Engl J Med 296:963–967, 1977.PubMedCrossRefGoogle Scholar
  2. 2.
    Larsson LI, Hirsch MA, Holst JJ, Ingemansson S, Kuhl C, Jensen SL, Lundqvist G, Rehfeld JF, Schwartz TW. Pancreatic somatostatinoma: clinical features and physiological implications. Lancet 1:666–668, 1977.PubMedCrossRefGoogle Scholar
  3. 3.
    Kaneko H, Yanaibara N, Ito S, Kusumoto Y, Fijita T, Ishikawa S, Sumida T, Sekiya M. Somatostatinoma of the duodenum. Cancer 44:2273–2279, 1979.PubMedCrossRefGoogle Scholar
  4. 4.
    Mao C, Shah A, Hanson DJ, Howard JM. Von Recklinghausen’s disease associated with duodenal somatostatinoma: Contrast of duodenal versus pancreatic somatostatinomas. J Surg Oncol 59:67–73, 1995.PubMedCrossRefGoogle Scholar
  5. 5.
    Krejs GJ, Orci L, Conlon JM, Ravazzola M, Davis GR, Raskin P, Collins SM, McCarthy DM, Baetens D, Rubenstein A, Aldor TA, Unger RH. Somatostatinoma syndrome: biochemical, morphologic, and clinical features. N Engl J Med 301:285–292, 1979.PubMedCrossRefGoogle Scholar
  6. 6.
    Wiedenmann B, Jensen RT, Mignon M, Modlin CI, Skogseid B, Doherty G. Preoperative diagnosis and surgical management of neuroendocrine gastroenteropancreatic tumors: General recommendations by a consensus workshop. World J Surg 22:309–318, 1998.PubMedCrossRefGoogle Scholar
  7. 7.
    O’Brien TD, Chejfec G, Prinz RA. Clinical features of duodenal somatostatinomas. Surgery 114:1144–1147, 1993.PubMedGoogle Scholar
  8. 8.
    Takizawa H, Kaneko H, Koike M, Hirose S, Asakura H. Small duodenal somatostatinoma with high plasma somatostatin level. Am J Gastroenterol 92:1063,1064, 1997.PubMedGoogle Scholar
  9. 9.
    Delcore R, Friesen SR. Gastrointestinal neuroendocrine tumors. J Am Coll Surg 178:187–211, 1994.PubMedGoogle Scholar

Copyright information

© Humana Press Inc 1998

Authors and Affiliations

  1. 1.Department of PathologyFalun Central HospitalFalunSweden
  2. 2.Department of PathologyUppsala University HospitalUppsalaSweden
  3. 3.Department of Internal MedicineAvesta HospitalAvestaSweden

Personalised recommendations