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Effect of water and food deprivation in pregnant rats on mitochondrial respiration and the state of gluconeogenesis in the rat pup liver

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Abstract

Wistar female rats were submitted to a water and food deprivation (food and water were restricted by 50% as compared to those consumed by control animals) during the entire pregnancy. There were 6 to 8 pups in the litters of experimental dams, the body weight of these pups being significantly lower than in control. In liver homogenates from deprived animals, intensity of gluconeogenesis was decreased by 50% or more, and gluconeogenesis precursors did not stimulate the glucose synthesis. Oxidation of pyruvate and malate as well as of caprylate by liver mitochondria remained significantly lower than in control from the postnatal day 10 to 2 months. A possible role of energetic disturbances in underdevelopment of animals submitted to the water and food deprivation during the intrauterine development is considered.

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References

  1. Young, C.H. and Rasmussen, K.M., Effects of Varying Degrees of Chronic Dietary Restriction in Rat Dams on Reproductive and Lactative Performance and Body Composition in Dams and Their Pups,Amer. J. Clin. Nutr., 1985, vol. 41, pp. 979–987.

    PubMed  CAS  Google Scholar 

  2. Poscalan, A. and Bertrand, M., Effects de la Restriction Alimentaire Globale sur le Development Embryo-Foetal chez la Rate,Ann. Rech. Vet., 1987, vol. 18, pp. 379–388.

    Google Scholar 

  3. Malyshev, A.B., Shevtsov, M.Ya., Shcheptseva, E.A., and Klimenko, A.I., Effect of the Calory-Restricted Diet on Regulation of Liver Cell Proliferation in Ontogenesis of Rat,Vsesoyuz. Konf. “Prodolzhitel’nost’ zhizni” (All-Union Conf.“Expectation of Life”), Kiev, 1991, pp. 82-83.

  4. Serova, L.V., Deryagina, S.N., Ivanova, S.Ya., and Nosovskii, A.N., Effect of Water Deprivation on the Maternal-Fetal System at Different Pregnancy Stages in Rats,Zh. Evol. Biokhim. Fiziol, 1995, vol. 31, pp. 611–617.

    PubMed  CAS  Google Scholar 

  5. Makhmudov, A.A., Effect of a Short-Term Starvation at the Lactation Period on the Development of Carbohydrate Digestive-Transport Conveyor,Cand. Sci. Dissertation, Tashkent, 1995.

  6. Koski, K.G. and Hill, F.T., Evidence for a Critical Period during Late Gestation When Maternal Carbohydrate is Essential for Survival of Newborn Rats,J. Nutr., 1990, vol. 120, pp. 1016–1027.

    PubMed  CAS  Google Scholar 

  7. Makhmudov, E.S., Akhmerov, R.N., Babaeva, R.N., and Baratova, G.H., Effect of Carbohydrate Metabolism Changes in the Process of Pregnancy on the Ability of the Rat Pup Liver Mttochondria to Oxidize Lipid Intermediate,Ontogenez, 1992, vol. 23, pp. 323–325.

    Google Scholar 

  8. Babaeva, R.N., Effect of Carbohydrate Metabolism Changes in the Process of Pregnancy on Reproductive Function and Postnatal Ontogenesis of Animals,Cand. Sci. Dissertation, Tashkent, 1995.

  9. L’vova, S.P. and Kazikhanova, H.N., Intensity of Gluconeogenesis in Liver Tissue of Rats of Different Ages,Ukr. Biokhim. Zh., 1991, vol. 63, no. 6, pp. 43–48.

    PubMed  CAS  Google Scholar 

  10. Chance, B. and Williams, G.R., Respiratory Enzymes in Oxidative Phosphorylation,J. Biol. Chem., 1955, vol. 217, pp. 429–438.

    PubMed  CAS  Google Scholar 

  11. Lowry, O.H., Rosenbrough, J., and Randall, R.J., Protein Measurement with Folin Phenol Reagent,J. Biol. Chem., 1951, vol. 193, pp. 265–275.

    PubMed  CAS  Google Scholar 

  12. Girard, J., Maternal—Fetal Relationships in Diabetes Mellitus, Fetal and Maternal Fuel Homeostasis,Diabetes: Proc. 13th Congr. Int. Diabets, Sydney, 1988, pp. 733-737.

  13. Vel’tishchev, Yu.E., Ermolaeva, M.V., Aponenko, L.R., and Knyazev Yu.A.,Obmen veshchestv u detei (Metabolism in Children), Moscow, 1983.

  14. Komarov, F.I., Korovkin, B.F., and Men’shikov, V.V.,Biokhimicheskie issledovaniya v kishechnike (Biochemical Studies in the Intestine), 2nd ed., Leningrad, 1981.

  15. Kaminskii, Yu.G. and Kosenko, E.A.,Paradoksy uglevodnogo obmena (Paradoxes of Carbohydrate Metabolism), Pushchino, 1988.

  16. Akhmerov, R.N., Cherlin, V.A., and Makhmudov, E.S., Oxidation of Different Substrates by Liver Mitochondria in Rat Pups during Early Postnatal Development,Ontogenez, 1990, vol. 21, pp. 639–642.

    PubMed  CAS  Google Scholar 

  17. Aw-Tan, Jones, D.P., Nutrient Supply and Mitochondrial Function,Ann. Rev. Nutr., 1989, vol. 9, pp. 229–251.

    Article  Google Scholar 

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Authors and Affiliations

  1. Institute of Physiology and Biophysics, Uzbekistan Academy of Sciences, Tashkent, Uzbekistan

    E. S. Makhmudov, R. N. Akhmerov, R. N. Babayeva, A. Kulkaraev & Z. Rasulova

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  1. E. S. Makhmudov
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  2. R. N. Akhmerov
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  3. R. N. Babayeva
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  4. A. Kulkaraev
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  5. Z. Rasulova
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Makhmudov, E.S., Akhmerov, R.N., Babayeva, R.N. et al. Effect of water and food deprivation in pregnant rats on mitochondrial respiration and the state of gluconeogenesis in the rat pup liver. J Evol Biochem Phys 36, 24–27 (2000). https://doi.org/10.1007/BF02738221

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  • DOI: https://doi.org/10.1007/BF02738221

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