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Applied Biochemistry and Microbiology

, Volume 36, Issue 1, pp 46–49 | Cite as

Obtaining a high-activity strain capable of producing the antistaphylococcal antibiotic batumin

  • V. V. Smirnov
  • L. N. Churkina
  • V. I. Perepnikhatka
  • N. S. Mukvich
  • A. D. Garagulya
  • E. A. Kiprianova
  • A. N. Kravets
  • S. A. Dovzhenko
Article

Abstract

The use of chemical and UV-induced mutageneses allowed us to increase the biosynthetic activity of the strain capable of producing new antistaphylococcal antibiotic, batumin. The strain ofPseudomonas batumici N17 producing 87–100 mg batumin per liter culture liquid was selected. Its activity was 3.5-5 times higher than the activity of the most potent natural strain.P. batumici N17 was shown to be stable in relation to the synthesis of batumin.

Keywords

Apply Biochemistry Parent Strain Minimal Inhibitory Concen Test Culture Cell Survival Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© MAIK “Nauka/Interperiodica” 2000

Authors and Affiliations

  • V. V. Smirnov
    • 1
  • L. N. Churkina
    • 1
  • V. I. Perepnikhatka
    • 1
  • N. S. Mukvich
    • 1
  • A. D. Garagulya
    • 1
  • E. A. Kiprianova
    • 1
  • A. N. Kravets
    • 2
  • S. A. Dovzhenko
    • 3
  1. 1.Institute of Microbiology and VirologyNational Academy of Sciences of UkraineKievUkraine
  2. 2.Institute of Epidemiology and Infectious DiseasesUkraine Ministry of HealthKievUkraine
  3. 3.State Research Center on AntibioticsMoscowRussia

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