Clinical Reviews in Allergy & Immunology

, Volume 17, Issue 1–2, pp 247–260 | Cite as

Pulmonary diseases other than asthma as potential targets for antileukotriene therapy

Clinical Sciences The Immunobiology of Leukotriene Inhibitors


A highly plausible rationale exists for implicating LTs in the pathogenesis of all the diseases considered in this discussion. In general, the weakest link is the paucity of therapeutic trials in humans. It is only recently that pharmacologic agents with acceptable potency and specificity have been available. As experience and comfort with these new anti-LT agents grow, it is anticipated that their application will be extended beyond asthma to the diseases discussed herein. For most of these diseases, a case can be made for the involvement of not only cysteinyl LTs, but also of LTB4 and 5-HETE. For this reason, it can be hypothesized that drugs that inhibit 5-LO metabolism at a proximal step (i.e., 5-LO or 5-LO activating protein) would appear to hold the most promise and versatility. It is hoped that the opportunity to test this hypothesis will be realized.


Chronic Obstructive Pulmonary Disease Cystic Fibrosis Pulmonary Hypertension Alveolar Macrophage Idiopathic Pulmonary Fibrosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Humana Press Inc 1999

Authors and Affiliations

  1. 1.Division of Pulmonary and Critical Care MedicineUniversity of Michigan Medical CenterAnn Arbor

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