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Directly observed treatment for tuberculosis

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Abstract

Directly Observed Treatment-Short Course (DOTS) has been a successful strategy in the global control of tuberculosis (TB) in adults. However, reports of implementation are scantily available in pediatric context. Present article reviews diagnostic uncertainties of TB in children commonly faced by physicians on account of the vague clinical presentations, unreliable tuberculin tests or TB score charts, non-specific hematological, biochemical or radiological evidence, difficulty in sputum expectoration and non-availability or ill-affordability of specialised tests. It also describes therapeutic problems arising due to the physician’s inexpertise, child’s incomprehensibility and parental anxiety. DOTS was found to be highly effective in 930 Indian children having TB over the 6-year study period, during which, a rise in number of cases with adult pattern of disease was also noted. The trend change in pediatric TB scenario is thought to have taken place due to malnutrition so widely prevalent in this country. Irrespective of the changing trend, DOTS strategy was found to be effective for all types of pediatric TB. A need, therefore, exists for quick resolution of the programme issues related to pediatric drug dispensing‘ physicians’ reservations about acceptance of strategy in this age-group, service-utilisation of DOTS providers for the selected cases unable to visit DOTS centres and giving executional priority to children during ongoing expansion of Revised National TB Control Programme (RNTCP) in country.

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References

  1. Kochi A. The global tuberculosis situation and the new control strategy of the World Health Organisation.Tubercle 1991 ; 72: 1–6.

    Article  PubMed  CAS  Google Scholar 

  2. Suryanarayana L, Suryanarayana HV, Jagannatha PS. Prevalence of pulmonary tuberculosis among children in a South Indian community.Ind J Tub 1999; 46:171–178.

    Google Scholar 

  3. Dharnidharka VR, Kandoth P. Pediatric inpatient morbidity patterns and drug usage in a teaching hospital serving an underdeveloped area.Indian J Public Health 1999; 43 (2): 64–66.

    PubMed  CAS  Google Scholar 

  4. Eamranond P, Jaramillo E. Tuberculosis in children: reassessing the need for improved diagnosis in global control strategies.Int J Tuberc Lung Dis 2001; 5 (7) : 594–603.

    PubMed  CAS  Google Scholar 

  5. World Health Organisation. Research for action: Understanding and controlling tuberculosis in India. WHO, 2000.

  6. Smith I, Stop TB. Is DOTS the answer?Ind J Tub 1999; 46: 81–90.

    Google Scholar 

  7. Chaulk CP, Moore-Rice K, Rizzo R, Chaisson RE. Eleven years of community-based directly observed therapy for tuberculosis.JAMA 1995; 274:945–951.

    Article  PubMed  CAS  Google Scholar 

  8. Sarin R, Dey LBS. Indian National Tuberculosis Programme: Revised Strategy.Ind J Tub 1995; 42 :95–100.

    Google Scholar 

  9. Arora VK, Sarin R. Revised National Tuberculosis Control Programme: Indian Perspective.Ind J Chest Dis Allied Sei 2000; 42:21–26.

    CAS  Google Scholar 

  10. Khatri GR. The Revised National Tuberculosis Control Programme: A status report on first 1,00,000 patients.Ind J Tub 1999; 46:157–166.

    Google Scholar 

  11. Khatri GR, Freiden TR. The status and prospects of tuberculosis control in India.Int J Tuberc lung Dis 2000; 4(3): 193–200.

    PubMed  CAS  Google Scholar 

  12. Raduta M. Prophylactic measures in tuberculosis hotbeds.Pneumologia 2001; 50 (3): 159–166.

    PubMed  CAS  Google Scholar 

  13. Norval PY, San KK, Bakhim T, Rith DN, Ahn DI, Blanc L. DOTS in Cambodia. Directly observed treatment with shortcourse chemotherapy.Int J Tuberc Lung Dis 1998; 2 (1): 44–51.

    PubMed  CAS  Google Scholar 

  14. Wu J, Xiong G, Feng S, Cao H, Rao Z, Jiang Tet al. Study on epidemic trend and control policy of tuberculosis in Sichuan province.Zhonghua Jie He He Hu Xi Za Zhi 2002; 25 (1): 12–14.

    PubMed  CAS  Google Scholar 

  15. World Health Organisation. Treatment of tuberculosis: Guidelines for National Programmes. WHO, 1993 :1–43.

  16. Royal Netherlands Tuberculosis Association and International Tuberculosis Surveillance Centre.Int J Tuberc Lung Dis 2001; 5 (2): 103–112.

    Google Scholar 

  17. Ramachandran P, Kripasankar AS, Duraipandian M. Short course chemotherapy for pulmonary tuberculosis in children.Ind J Tub 1998; 45: 83–87.

    Google Scholar 

  18. Suryanarayana L, Jagannatha PS. Scoring method for diagnosis of tuberculosis in children: An evaluation.Ind J Tub 2001; 48 : 101–103.

    Google Scholar 

  19. Van Rheenen P. The use of the pediatric tuberculosis score chart in an HIV-endemic area.Trop Med Int Health 2002; 7(5): 435–441.

    Article  PubMed  Google Scholar 

  20. Hilman BC. Pediatric tuberculosis: problems in diagnosis and issues in management.J La State Med Soc 1998; 150 (12) : 601–610.

    PubMed  CAS  Google Scholar 

  21. Central TB Division. Managing the Revised National Tuberculosis Control Programme in your area —A training course. Modules 1–4. Directorate General of Health Services, New Delhi, July 2001:1–138.

    Google Scholar 

  22. Juvekar SK, Morankar SN, Dalai DB, Rangan SG, Khanvilkar SS, Vadair ASet al. Social and operational determinants of patient behaviour in lung tuberculosis.Ind J Tub 1995; 42: 87–94.

    Google Scholar 

  23. Balasubramanian VN, Oomen K, Samuel R. DOT or not ? Direct observation of anti-tuberculosis treatment and patient outcomes, Kerala State, India.Int J Tuberc Lung Dis 2000; 4(5): 409–413.

    PubMed  CAS  Google Scholar 

  24. Global Alliance for TB drug development. Scientific blueprint for tuberculosis drug development.Tuberculosis (Edinb) 2001; 81 suppl 1:1–52.

    Article  Google Scholar 

  25. Arora VK. Relevance of control programme in multi-drug resistant tuberculosis scenario [Editorial].India Chest 2001; 2(6): 301–302.

    Google Scholar 

  26. Castillo H del, Palacios E, Mukherjee JS, Joseph JK. Pediatric MDR TB.Int J Tuberc Lung Dis 2002; 6 (10): S158.

    Google Scholar 

  27. Leung AN, Muller NL, Pineda PR, Fitzgerald JM. Primary tuberculosis in childhood: radiographie manifestations.Radiology 1992; 182 : 87–91.

    PubMed  CAS  Google Scholar 

  28. Ibadin MO, Oviawe O. Trend of childhood tuberculosis in Benin City, Nigeria.Ann Trop Pediatr 2001; 21 (2): 141–145.

    Article  CAS  Google Scholar 

  29. Pineda PR, Leung A, Muller NL, Allen EA, Black WA, Fitzgerald JM. Intrathoracic paediatric tuberculosis: a report of 202 cases.Tuber Lung Dis 1993; 74 (4) : 261–266.

    Article  PubMed  CAS  Google Scholar 

  30. Sassan-Morokro M, De Cock KM, Ackah A, Vetter KM, Doorly R, Brategaard K, Coulibaly Det al. Tuberculosis and HIV infection in children in Abidjan.Trans R Soc Trop Med Hyg 1994; 88 (2): 178–181.

    Article  PubMed  CAS  Google Scholar 

  31. Sharma SK, Saha PK, Dixit Y, Siddaramaiah NH, Seth P, Pande JN. HIV sero-positivity among adult tuberculosis patients in Delhi.Ind J Chest Dis Allied Sci 2000; 42:157–160.

    CAS  Google Scholar 

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Correspondence to V. K. Arora.

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Arora, V.K., Gupta, R. Directly observed treatment for tuberculosis. Indian J Pediatr 70, 885–889 (2003). https://doi.org/10.1007/BF02730593

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