The Indian Journal of Pediatrics

, Volume 66, Issue 4, pp 613–620 | Cite as

Pediatric depression and psychopharmacology

  • Prabhat Sitholey
Symposium : Behavioural Pediatrics-II


Children can and do have depression which is similar to and continuous with that in adults. It can be diagnosed and treated similarly. Clinical evaluation reveals depression and laboratory tests are not required. It may be comorbid with other psychiatric or physical disorders. It causes considerable distress and impairment and suicide can be one serious sequel. Relapse or recurreneces can occur. Etiology of depression is uncertain though hypotheses of psychogenesis or biogenesis exists. Psycho-pharmacological advances have helped in understanding etiology of depression and also in its effective treatment. So far, fluoxetine in the only antidepressant shown to be effective though others are also used. Antidepressants need to be given for one year or more.

Key words

Pediatric Depression Antidepressants 


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  1. 1.
    Fleming JE, Offord DR. Epidemiology of childhood depressive disorders: a critical review.J Am Acad Adolesc Psychiatry 1990; 29: 571–580.CrossRefGoogle Scholar
  2. 2.
    Kashani JH, Beck NC, Hoeper EWet al. Psychiatric disorders in a community sample of adolescents.Am J Psychiatry 1987; 144: 584–589.PubMedGoogle Scholar
  3. 3.
    Kashani JH, Carlson GA, Beck NCet al Depression, depressive symptoms, and depressed mood among a community sample of adolescents.Am J Psychiatry 1987; 144: 931–934.PubMedGoogle Scholar
  4. 4.
    Lewinsohn PM, Clarke GN, Seeley JR, Rhode P. Major depression in community adolescents: age at onset, episode duration, and time to recurrence.J Am Acad Child Adolesc Psychiatry 1994; 33 : 809–818.PubMedCrossRefGoogle Scholar
  5. 5.
    Garrison CZ, Addy CL, Jackson KL, Mekeown RE, Weller JL. Major depressive disorder and dysthymia in young adolescents.Am J Epidemiol 1992; 135: 792–802.PubMedGoogle Scholar
  6. 6.
    Lewinsohn PM, Hops H, Roberts RE, Seeley JR, Andrews JA. Adolescent psychopathology, 1: prevalence and incidence of depression and other DSM-3-R disorders in high school students.J Abnorm Psychol 1993; 102: 133–144.PubMedCrossRefGoogle Scholar
  7. 7.
    Chambers WJ, Puig-Antich J, Tabrizi MA, Davies M. Psychotic symptoms in prepubertal major depressive disorder.Arch Gen Psychiatry 1982; 39: 921–927.PubMedGoogle Scholar
  8. 8.
    Ryan ND, Puig-Antich J, Ambrosini Pet al. The clinical picture of major depression in children and adolescents.Arch Gen Psychiatry 1987; 44: 854–861.PubMedGoogle Scholar
  9. 9.
    Mitchell J, McCauley E, Burle PM, Mass SJ. Phenomenology of depression in children and adolescents.J Am Acad child Adolsec Psychiatry 1988; 1: 12–20.CrossRefGoogle Scholar
  10. 10.
    Srivastava RP. A psychiatric study of children and adolescents (6-16 years) presenting with prominent affective symptoms. Thesis for MD (Psychiatry), University of Lucknow, Lucknow, 1989.Google Scholar
  11. 11.
    Prakash S. Childhood depression in a rapidly developing society-some developmental issues and therapeutic considerations. In: Channabasavanna SM, Shah SA (eds.)Affective Disorders : Recent Research and Related Developments, Bangalore : National Institute of Mental Health and Neurosciences. 1987; 205–212.Google Scholar
  12. 12.
    Srinath S, Bavle A. Manic depressive psychosis in children. In: Channabasvanna SM, Shah SA (eds.)Affective Disorders : Recent Research and Related Developments Bangalore : National Institute of Mental Health and Neurosciences. 1987; 213–220.Google Scholar
  13. 13.
    McKnew DH Jr, Cytryn L. Urinary metabolites in chemically depressed children.J Am Acad Child Psychiatry 1979; 18: 608–615.PubMedCrossRefGoogle Scholar
  14. 14.
    Khan AU. Biochemical profile of depressed adolescents.J Am Acad Child Psychiatry 1987; 26: 873–878.CrossRefGoogle Scholar
  15. 15.
    Carstens ME, Engelbrecht AH, Russel VA, Van Zyl AM, Talijaard JJF. Biological markers in juvenile depression.Psychiatry Res 1988; 23: 78–88.CrossRefGoogle Scholar
  16. 16.
    Jensen JB, Garfinkel BD. Growth hormone dysregulation in children with major depressive disorder.J Am Acad child Adolesc Psychiatry 1990; 29: 295–301.PubMedCrossRefGoogle Scholar
  17. 17.
    Puig-Antich J, Novacenko H, Davies Met al. Growth hormone secretion in prepubertal children with major depression. 1: Final report on response to insulin-induced hypoglycemia during a depressive episode.Arch Gen Psychiatry 1984; 41: 455–460.PubMedGoogle Scholar
  18. 18.
    Tyrer SP, Barret ML, Berney TPet al. The dexamethasone suppression test in children: lack of an association with diagnosis.Brit J Psychiatry 1991; 159 (supplement 11) 41–48.Google Scholar
  19. 19.
    Modai I, Apter A, Meltzer M, Tyano S, Walerski A, Jerushalmy Z. Serotonin up-take by platelets of sucidal and aggressive adolescent psychiatric inpatients.Neuropsychobiology 1989; 21: 9–13.PubMedCrossRefGoogle Scholar
  20. 20.
    Ambrosini PJ, Metz C, Arora RC, Lee JC, Kregel L, Meltzer HY. Platelet imipramine binding in depressed children and adolescents.J Am Acad Child Adolesc Psychiatry 1992; 31 (2); 298–305.PubMedCrossRefGoogle Scholar
  21. 21.
    Rogeness G A, Mitchell EL, Custer GJ, Harris WR. Comparison of whole blood serotonin and platelet MAO in children with schizophrenia and major depressive disorder.Biol Psychiatry 1985; 20: 270–275.PubMedCrossRefGoogle Scholar
  22. 22.
    Joshi G, Sitholey P, Gujrati VRet al. Platelet serotonin kinetics in depressed adolescents.Biogenic Amines 1997; 13(6): 591–602.Google Scholar
  23. 23.
    Ryan ND, Birmaher B, Perel JMet al. Neuroendocrine response to L-5-hydroxytryptophan challenge in prepubertal major depressionvs normal children.Arch Gen Psychiatry 1992; 49 (11): 843–851.PubMedGoogle Scholar
  24. 24.
    Emslie GJ, Rush AJ Weinberg WAet al. A double blind randomized placebo controlled trial of fluoxetine in children and adolescents with depression.Arch Gen Psychiatry 1997; 54: 1031–1037.PubMedGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 1999

Authors and Affiliations

  1. 1.Department of PsychiatryKing George’s Medical CollegeLucknow

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