Effect of lactobacillus supplementation on immune status of malnourished pre-school children
- 32 Downloads
The present study was undertaken to assess the effect of Lactobacillus supplementation on immune response of pre school children. Thirty malnourished (grade I and grade II) preschool (3–5 years old) children were selected for the study. These were further categorized into three groups ‘A’, ‘B’ and ‘C’, each group comprising of 10 individuals. Groups ‘Ar and ‘B’ were given lactobacillus supplementation 1.0 x 108 million viable spores/day/child and 2.0 x 108 million of viable spores/day/child for 90 days respectively. Group ’C served as control. Serum adenosine deaminase (ADA) which is an important immunoenzyme marker for assessing lymphocyte function and proliferation was determined at different intervals. The results revealed that lactobacillus supplementation at level of 1.0 x 108 million viable spores/day/child for 15 days along with regular diet significantly improved the ADA levels of pre-school children indicating therapeutic value of lactobacillus as supplementation to malnourished pre-school children.
Key wordsLactobacillus Adenosine deaminase (ADA) Pre-school children
Unable to display preview. Download preview PDF.
- 1.Bhaskaram and Vinodini Reddy. Cell mediated immunity in protein calorie malnutrition.J Trop Pediatr 1974; 20: 284–287.Google Scholar
- 3.Glusti G. Adenosine deaminase. In: Bergmeyer HU (ed).Methods in Enzymatic Analysis. Vol.2, New York, Academic Press, 1974; pp. 1092–1099.Google Scholar
- 4.Khedekar CD, Dave JM, Sannabhadtiss. Effect of feeding acidophilus milk on the fecal lactobacilli and coliform counts on human volunteers.Ind. Dairyman 1990; 43: 237–241.Google Scholar
- 6.Khosla SN, Dinesh Kumar and Singh V. Lymphocytic adenosine deaminase activity in typhoid fevers.Postgrad Me J 1992; 68: 268–271.Google Scholar
- 7.Lakshmi V, Rao RR, Nayana Joshi and Rao PN. Serum adenosine deaminase activity in bacillary (or) paucibacillary pulmonary tuberculosis.Indian J Pathol Microbio 1992; 35(1): 48–52.Google Scholar
- 8.Majamma H, Isolauri E, Sexelin M and Vesikar T. Lactic bacteria in the treatment of acute rotavirus gastroenterities.J Pediatric Gastronenterol 1995; 20(3): 333–338.Google Scholar
- 10.Peridigon G, Nader M.E. de Macias, Alvarez S, Goliver S. and Pesce de Ruiz Holgado AA. Enhancement of immune response in mice fed streptococcus thermophilus and lactobacillus acidiophilus.J D airy Sci 1987; 70: 919–926.Google Scholar
- 11.Peridigon G, Nader M E, de Marias, Alvarez Goliver S and A.A. Pesce de Ruiz Holgado. Systemic augmentation of the immune response in mice by feeding fermented milks withLb.Casei andLb. acidophilus immunology 1988; 63: 17–23.Google Scholar
- 12.Peridigon G, Susana AI Varez and Aida Pesce De Ruiz Holgado. Immuno adjuvant activity of oralLactobacillus casei: Influence of dose on the secretory immune response and protective capacity in intestinal infection.J. Dairy Research 1991; 58: 485–496.Google Scholar
- 13.Prajapati JB. Fundamentals of dairy microbiology. Akta Prakashan, Nadiad, India, 1995: 99–117.Google Scholar
- 15.Sellar RL. Acidophillus products. In: Robinson RK (ed).Therapeutic Properties of Fermented Milks Elsevier applied Science, London, 1991; pp. 81–85.Google Scholar