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The Indian Journal of Pediatrics

, Volume 70, Issue 9, pp 759–760 | Cite as

Sinus histiocytosis with massive lymphadenopathy: Complicated by autoimmune hemolytic anemia

  • Penukonda Sasi Kiran
  • Vasantha Prema Sowdi
  • Sumanth B. Shetty
  • U. Venugopal
  • S. Parameshwariah
  • Edwin Dias
  • C. S. Kamala
Clinical Brief

Abstract

Sinus histiocytosis with massive lymphadenopathy is a rare histiocytic disorder with very few case reports in Indian literature. Immunological abnormalities have been documented in few cases. We report one such case of a child presenting with generalized lymphadenopathy and complicated by autoimmune hemolytic anemia, suggestive of an associated immune dysfunction.

Key words

Sinus histiocytosis with massive lymphadenopathy Immunological abnonnalities Hemolytic anemia 

References

  1. 1.
    Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: A newly recognized benign clinicopathological entity.Arch pathol 1969; 87: 63–70.PubMedGoogle Scholar
  2. 2.
    Sandhyamani S, Mathur M, Marwaha R, Choudhary VP, Sharma SK, Guleria JS. Sinus histiocytosis with massive lymphadenopathy.Indian J Pathol Microbiol 1984; 27: 99–103.Google Scholar
  3. 3.
    Sharma SK, Kapoor P, Pande JN, Guleria JS. Sinus histiocytosis with massive lymphadenopathy (SHML).J Assoc Phys India 1982; 30: 249–250.Google Scholar
  4. 4.
    Vasantha T, Dawar R, Arya LS. Sinus histiocytosis with massive lymphadenopathy in children.Indian Pediatr 2002; 39: 764–769.Google Scholar
  5. 5.
    Foucar E, Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease): Review of the entity.Semin Diagn Pathol 1990; 7:19–73.PubMedGoogle Scholar
  6. 6.
    Sanchez R, Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy. An analysis of 113 cases with special emphasis on its extra nodal manifestations (Abstr)Lab invest 1977; 36: 21–22.Google Scholar
  7. 7.
    Becroft DMO, Dix MR, Gillman JC, Mac Gregor BJL, Shaw RL. Benign sinus histiocytosis with massive lymphadenopathy: Transient immunological abnormalities in a child with mediastinal involvement.J Clin Pathol 1973; 26:463–469.PubMedCrossRefGoogle Scholar
  8. 8.
    Foucar E, Rosai J, Dorfman RF, Eryman JM. Immunological abnormalities and their significance in Sinus histiocytosis with massive lymphadenopathy.Am J Clin Pathol 1984; 82:515–525.PubMedGoogle Scholar
  9. 9.
    Grabczynska SA, Toh CT, Francis N, Costello C, Bunker CB. Rosai-Dorfman disease complicated by autoimmune haemolytic anaemia; Case report and review of a multisystem disease with cutaneous infiltrates.Br J Dermatol 2001; 145(2): 323–326.PubMedCrossRefGoogle Scholar
  10. 10.
    Foucar E, Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy: An analysis of 14 deaths occurring in a patient registry.Cancer 1984; 9:1834–1840.CrossRefGoogle Scholar
  11. 11.
    Rosai J, Dorfman RF. Sinus histiocytosis with massive lymphadenopathy-A pseudolymphomatous benign disorder.Cancer 1972; 30:1174–1188.PubMedCrossRefGoogle Scholar
  12. 12.
    Komp DM. The treatment of sinus histiocytosis with massive lymphadenopathy (Rosai-Dorfman disease)Semin Diagn Pathol 1990; 7:83–86.PubMedGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2003

Authors and Affiliations

  • Penukonda Sasi Kiran
    • 2
  • Vasantha Prema Sowdi
    • 1
    • 2
  • Sumanth B. Shetty
    • 2
  • U. Venugopal
    • 2
  • S. Parameshwariah
    • 1
    • 2
  • Edwin Dias
    • 2
  • C. S. Kamala
    • 2
  1. 1.Department of PathologyK.S. Hegde Medical AcademyMangaloreIndia
  2. 2.Department of PediatricsK.S. Hegde Medical AcademyMangaloreIndia

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