Immune functions in splenectomized thalassaemic children
A prospective study to assess the immune functions in splenectomized thalassaemic children. Children were those registered in the Thalassemia major. There were 10 splenectomized children (Group 1), 10 nonsplenectomized children and 6 age-matched control (Group 3). All children were shown to be HIV seronegative. The mean concentrations of serum IgG and IgA were higher in Group 1 as compared to Groups 2 and 3 but the differences were not statistically significant. Nitroblue tetrazolium (NBT) dye reduction by stimulated polymorphonuclear leukocytes was normal in both study and control groups and the differences were not statistically significant. However, NBT reduction in the unstimulated state was much higher in Group 2 as compared to Groups 1 and 3. Phytohaemagglutinin induced mitogen proliferation was normal in all 3 groups. Children in Group 1 not only had a significantly higher absolute lymphocyte count but also had a lower CD4JCD8 ratio as compared to Groups 2 and 3. Splenectomy does appear to alter the immune status of thalassemic children but the exact mechanism by which this occurence is not clear.
Key wordsThalassemia Transfusion programme Splenectomy
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- 1.Bunn HF. Disorders of hemoglobin. In:Harrison’s Principles of Internal Medicine, 13th. Edn, eds. Isselbacher KJ, Braunwald E, Wilson JD. New York, McGraw-Hill, Inc., 1994, 1734–1743.Google Scholar
- 2.Lukens JN. The thalassemias and related disorders: quantitative disorders of hemoglobin synthesis. In: Lee GR, Bithell TC, Foerster Jet al. Wintrobe’s Clinical Hematology, 9th. Edn. Philadelphia, Lea & Febiger, 1993, 1102–45.Google Scholar
- 3.Rosse W, Bunn HF. Hemolytic anemias. In: Isselbacher KJ, Braunwald E, Wilson JDet al. Harrison’s Principles of Internal Medicine, 13th. Edn. New York, McGraw-Hill, Inc., 1994, 1743–1754.Google Scholar
- 10.Seitandis B, Michas A, Angelopoulos B. Serum immunoglobulin levels in beta-thalassemia after splenectomy.Acta Haematol1971, 46: 267–270Google Scholar
- 11.Actam VH.Immunoglobulin levels in children with homozygous beta-thalassemia.Acta Paediatr Scand 1976, 65:23–27.Google Scholar
- 15.Centers for Disease Control and Prevention. Age -adjusted T4 (CD4+) normal lymphocyte counts in healthy children.MMWR 1991, 40:1–13.Google Scholar
- 18.Gofstein R, Gellis SS. Splenectomy in infancy and childhood; question of overwhelming infection following operation.Am J Bis Child 1956, 91: 566–569.Google Scholar
- 22.Watson JG, Bird AG.Handbook of Immunological Investigations in Children. London, Wright, 1990, 214–252.Google Scholar