The Indian Journal of Pediatrics

, Volume 70, Issue 10, pp 837–838 | Cite as

Aniridia and wilm’s tumor

  • Manisha Nada
  • K. N. Rattan
  • Sarita Magu
  • Sanjeev Parshad
Clinical Brief


Aniridia (absence of iris) is a congenital, bilateral, uncommon panocular disorder. Whereas the occurrence of aniridia in the general population is 1:50000, it is present in about 1 in 70 patients with Wilm’s tumor. This aniridia is sporadic and Wilm’s tumor in these cases presents at an unusually early age. Aniridia was present in two cases out of 60 cases of Wilm’s tumor operated at PGIMS, Rohtak. Both cases presented below two years of age. The recognition of a child with sporadic aniridia should alert to the increased risk of development of Wilm’s tumor.

Key words

Aniridia Wilm’s tumor WAGR syndrome 


  1. 1.
    Neher EM. Aniridia congenita, irideremia.Am J Ophthalmol 1938; 21: 293–258.Google Scholar
  2. 2.
    Brusa P, Toricelli C. Nephroblastoma de Wilm’s ed affezioni renali congenite nella casistica dell Milano Minerva Paediat 1953; 5: 457–458.Google Scholar
  3. 3.
    Sg Snyder HM, P’Angio GJ, Evans EA, Ranly RB. Pediatric oncology. In Wilsh PC, Retik BA, Vaughan ED, Wein AJ, eds.Campbell’s Urology. Vol. 2. USA; WB Saunders, 1998; 2110–2256.Google Scholar
  4. 4.
    Kullendorff CM, Wiebe T. Wilm’s tumor in infancy.Acta Paediatr 1998; 87: 747–750.PubMedCrossRefGoogle Scholar
  5. 5.
    Nelsonet al. Aniridia: A review.Surg Ophthalmol 1984; 28 (6) : 621–642.CrossRefGoogle Scholar
  6. 6.
    Godde-Salz E, Behnke H. Aniridia, mental retardation and an unbalanced reciprocal translocation of chromosomes 8 and 11 with an interstitial deletion of lip.Eur J Paediatr 1981; 136: 93–96.CrossRefGoogle Scholar
  7. 7.
    Narahara K, Kikkawa K, Kimira Set al. Regional mapping of catalase and Wilm’s tumor: Aniridia, genitourinary anomalies and mental retardation triad loci to the chromosome segment 11 p 1350-1306.Hum Genet 1984; 66 : 181.PubMedCrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2003

Authors and Affiliations

  • Manisha Nada
    • 1
  • K. N. Rattan
    • 2
  • Sarita Magu
    • 3
  • Sanjeev Parshad
    • 4
  1. 1.Department of OphthalmologyPt. B.D. Sharma PGIMSRohtak, HaryanaIndia
  2. 2.Department of Pediatric SurgeryPt. B.D. Sharma PGIMSRohtak, HaryanaIndia
  3. 3.Department of RadiologyPt. B.D. Sharma PGIMSRohtak, HaryanaIndia
  4. 4.Department of SurgeryPt. B.D. Sharma PGIMSRohtak, HaryanaIndia

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