The Indian Journal of Pediatrics

, Volume 70, Issue 7, pp 553–556 | Cite as

Reduced exercise capacity in non-cystic fibrosis bronchiectasis

  • Soumya Swaminathan
  • K. V. Kuppurao
  • N. Somu
  • V. K. Vijayan
Original Article


Objective : Bronchiectasis not due to cystic fibrosis is usually a consequence of severe bacterial or tuberculous infection of the lungs, which is commonly seen in children in developing countries. Our aim was to study its functional sequelae and affect on work capacity in children.Methods : Seventeen children (7-17 years of age) with clinical and radiological evidence of bronchiectasis of one or both lungs were studied at the Cardiopulmonary Unit of the Tuberculosis Research Centre. Pulmonary function tests including spirometry and lung volume measurements were performed. Incremental exercise stress test was done on a treadmill, and ventilatory and cardiac parameters were monitored. Control values were taken from a previous study.Results : Children with bronchiectasis had lower forced vital capacity (FVC) (1.1 + 0.4 L versus 1.5 + 0.4 L, p=0.003) and FEV, (0.95 ±0.2 L versus 1.4 ±0.3 L, p<0.002) compared to age- and sex-matched healthy controls. The patient group had significantly higher residual lung volumes (0.7 ±0.3 L versus 0.4 + 0.1 L, p<0.02). At maximal exercise, they had lower aerobic capacity (28 +- 6 ml/min/kg versus 38 ±5 ml/min/kg, p<0.0001) and maximal ventilation (24 ±8 L/min versus 39 ±10 L/min, p<0.001). At maximal exercise, while none of the controls desaturated, oxygen saturation fell below 88% in eight of 17 patients.Conclusion : The findings show that children and adolescents with non-cystic fibrosis bronchiectasis have abnormal pulmonary function and reduced exercise capacity. This is likely to interfere with their life as well as future work capacity. Efforts should be made to minimize lung damage in childhood by ensuring early diagnosis and instituting appropriate treatment of respiratory infections.

Key words

Bronchiectasis Exercise limitation Aerobic capacity Children Pulmonary function 


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  1. 1.
    Dagli E. Non cystic fibrosis bronchiectasis.Pediatr Respir Rev 2000; 1: 64–70.CrossRefGoogle Scholar
  2. 2.
    Sethi GR, Batra V. Bronchiectasis: causes and management.Indian J Pediatr 2000; 67(2): 133–139.PubMedGoogle Scholar
  3. 3.
    Nixon PA, Orenstein DM. Exercise testing in children.Pediatr Pulmonol 1988; 5: 107–122.PubMedCrossRefGoogle Scholar
  4. 4.
    Platzker ACG, Keens TG. Pulmonary function testing in pediatric patients. In Wilson AF, ed.Pulmonary Function Testing: Indications and Interpretation. Florida, Grune and Stratton, 1985; 275–292.Google Scholar
  5. 5.
    Swaminathan S. Exercise testing in children: Indications and Technique.Indian J Pediatr 1991; 58: 305–330.PubMedGoogle Scholar
  6. 6.
    Nixon PA, Orenstein DM, Kelsey SF, Doershuk CF. The prognostic value of exercise testing in patients with cystic fibrosis.N Engl J Med 1992; 327: 1785–1788.PubMedCrossRefGoogle Scholar
  7. 7.
    Corey M, McLoughlin MC, William M and Levison H. A comparison of survival, growth and pulmonary function in patients with cystic fibrosis in Boston and Toronto.J Clin Epidemiol 1988; 41: 583–591.PubMedCrossRefGoogle Scholar
  8. 8.
    Swaminathan S, Vijayan VK, Venkatesan P, Kuppu Rao KV. Aerobic capacity and cardiopulmonary response to exercise in healthy south Indian children.Indian Pediatr 1997; 34: 112–118.PubMedGoogle Scholar
  9. 9.
    Chowgule RV, Shetye VM, Parmer JR. Lung function tests in normal Indian children.Indian Pediatr 1995; 32: 185–191.PubMedGoogle Scholar
  10. 10.
    Vijayan VK, Reetha AM, Kuppurao KV, Venkatesan P, Thilakavathy S. Pulmonary function in normal South Indian children aged 7 to 19 years.Indian J Chest Dis Allied Sci 2000; 42: 147–156.PubMedGoogle Scholar
  11. 11.
    Polgar G, Promadhat V.Pulmonary Function Testing in Children: Techniques and Standards. Philadelphia, WB Saunders, 1971; 88–95.Google Scholar
  12. 12.
    Morgan MDL. Exercise testing. In Hughes JMB, Pride NB, eds.Lung Function Tests: Physiological Principles and Clinical Applications. WB Saunders, UK, 2000; 134–148.Google Scholar
  13. 13.
    Gulmans VAM, de Meer Brackel HJL, Helders PJM. Maximal work capacity in relation to nutritional status in children with cystic fibrosis.Eur Respir J 1997; 10: 2014–2017.PubMedCrossRefGoogle Scholar
  14. 14.
    De Meer Gulmans VAM, van der Laag J. Peripheral muscle weakness and exercise capacity in children with cystic fibrosis.Am J Respir Crit Care Med 1999; 159: 748–754.PubMedGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2003

Authors and Affiliations

  • Soumya Swaminathan
    • 3
  • K. V. Kuppurao
    • 3
  • N. Somu
    • 1
  • V. K. Vijayan
    • 2
  1. 1.Institute of Child Health and Hospital for ChildrenChennai
  2. 2.Vallabhbhai Patel Chest InstituteUniversity of DelhiDelhiIndia
  3. 3.Tuberculosis Research CentreChennaiIndia

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