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Fetal intracranial hemorrhage due to antenatal low dose aspirin intake

  • C. K. Sasidharan
  • P. M. Kutty
  • Ajithkumar
  • N. Sajith
Clinical Brief

Abstract

Antenatal intake of low dose aspirin is advised 1,2 for prevention of pregnancy induced hypertension, intrauterine growth retardation and pre-term labour. Aspirin has an anticoagulant effect due to its action onCyclo-oxygenase and vitamin K dependant coagulation factors. It can readily cross the placental barrier and be a potential cause for bleeding tendency in the fetus. Fetal intracranial hemorrhage, following low dose aspirin administration in a mother and subsequent effect after delivery is being reported.

Key words

Foetal Intracranial haemorrhage Antenatal aspirin 

References

  1. 1.
    Sibi BM, Caritis SN, Thom Eet al. Prevention of pre-eclampsia with low dose aspirin in healthy nulliparous women.N Eng J Med 1993; 329: 1213–1218.CrossRefGoogle Scholar
  2. 2.
    Imperial TF and Petrulis AS. A meta-analysis of low dose aspirin for the prevention of pregnancy induced hypertensive disease.JAMA 1991; 266: 260–264.CrossRefGoogle Scholar
  3. 3.
    Louden KA, Kilbey MD. Low dose aspirin: The rationale for preventing pre-eclampsia and intrauterine growth retardation : A role after CLASP. In Bonnar J, ed.Recent Advances in Obstetrics and Gynecology. New York: Churchill Livingstone, 1995; 15–33.Google Scholar
  4. 4.
    Rumack CM, Guggenheim MA, Rumack BHet al. Neonatal Intracranial hemorrhage and maternal use of aspirin.Obstet Gynecol 1981; 58 (Suppl): 525–565.Google Scholar
  5. 5.
    Valcamonico A, Foschini M, Soregaroli Met al. Low dose aspirin in pregnancy; a clinical and biochemical study of effects on the newborn.J Perinat Med 1993; 21(3): 235–240.PubMedCrossRefGoogle Scholar
  6. 6.
    Roy AF. Ultrasound Evaluation of the Fetal Neural Axis. In Callen PW, ed.Ultrasonography in Obstetrics and Gynecology. 3rd edn. Philadephia; W.B. Saunders Company, 1994; 189–218.Google Scholar
  7. 7.
    Sherer DM, Anyaegbunam A, Onyeige C. Antepartum fetal intracranial hemorrhage, predisposing factors and prenatal sonography: A review.Am J Perinatal 1998; 15(7) : 431–441.CrossRefGoogle Scholar

Copyright information

© Dr. K C Chaudhuri Foundation 2001

Authors and Affiliations

  • C. K. Sasidharan
    • 1
  • P. M. Kutty
    • 1
  • Ajithkumar
    • 1
  • N. Sajith
    • 1
  1. 1.Division of Neonatology, Dept. of PediatricsInstitute of Maternal and Child Health, Medical CollegeKeralaIndia

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