The Indian Journal of Pediatrics

, Volume 57, Issue 2, pp 235–243 | Cite as

Cytogenetic studies in a population suspected to have chromosomal abnormalities

  • V. C. Shah
  • D. S. Krishna Mutiny
  • Sabita K. Murthy
Symposium : Chromosomal Disorders


The present study describes the cytogenetic findings in cases suspected with chromosomal abnormalities, in cases of mental retardation, multiple congenital malformations, clinical features of Down’s syndrome, Klinefelters’s syndrome, Turner’s syndrome, ambiguous sex, sterility, amenorrhea and history of repeated spontaneous abortions in couples. Cytogenetic studies were done in 144 of the total 205 cases. In all, 57 (39.58%) were shown to have chromosomal abnormality and of these, 34 cases (25.7%) were Down’s syndrome. Sex chromosome abnormality was found in 19 cases (13.2%). The results confirm the significant contribution of chromosomal abnormalities in the genesis of mental retardation, and abnormal sexual development.

Key words

Ambiguous sex Congenital anomalies Down’s syndrome Hermaphrodite Mental retardation Polymorphism 


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Copyright information

© Dr. K C Chaudhuri Foundation 1990

Authors and Affiliations

  • V. C. Shah
    • 1
  • D. S. Krishna Mutiny
    • 1
  • Sabita K. Murthy
    • 1
  1. 1.Department of Zoology (Cell Biology)University School of Sciences,Gujarat UniversityAhmedabad

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