Skip to main content
SpringerLink
Log in

Long-term drug treatment of asthma in children

  • Asthma: Inflammatory Mechanisms And Clinical Management With β2-Adrenoceptor Agents
  • Published:
Lung Aims and scope Submit manuscript

Abstract

In this short review the pharmacologic and clinical effect of antiasthma drugs in children that is,β 2-agonists, theophylline, anticholinergics, disodiumcromoglycate/nedocromil sodium, and inhaled corticosteroids are described. Furthermore, a medication plan for maintenance treatment is presented.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Barnes P (1986) Neural control of human airways in health and disease. State of the art. Am Rev Respir Dis 134:1289–1314

    PubMed  CAS  Google Scholar 

  2. Kay AB, Nadel JA, Henson PM, Irvin C, Hunninghake GW, Lichtenstein LM (1989) The role of inflammatory cells and their mediators in bronchial hyperresponsiveness. In: Holgate ST, Burney PJ, Drazen JM, Hargreave FE, Kay AB, Kerrebijn KF, Reid LM (eds) The role of inflammatory mediators in bronchial hyperresponsiveness. Blackwell Scientific Publications, Oxford (London, Edinburgh, Boston, Melbourne), pp 151–178

    Google Scholar 

  3. Drazen JM, Hirschman C, Macklem PT, Pauwels R, Permutt S, Persson C (1989) Physiology. In: Holgate ST, Burney PJ, Drazen JM, Hargreave FE, Kay AB, Kerrebijn KF, Reid LM (eds) The role of inflammatory mediators in bronchial hyperresponsiveness, Blackwell Scientific Publications, Oxford, pp. 108–150

    Google Scholar 

  4. Kerrebijn KF, Howell JBC, Jongejan RC, Postma DS, Sears MR, Woolcock AJ. Clinical presentation of airway hyperresponsiveness. In: Holgate ST, Burney PJ, Drazen JM, Hargreave FE, Kay AB, Kerrebijn KF, Reid LM (1989) (eds) The role of inflammatory mediators in bronchial hyperresponsiveness. Blackwell Scientific Publications, Oxford, pp. 1–35

    Google Scholar 

  5. Anderson SD (1985) Issues in exercise-induced asthma. J Allergy Clin Immunol 76:763–772

    Article  PubMed  CAS  Google Scholar 

  6. Strope GL, Stempel DA (1984) Risk factors associated with the development of chronic lung disease in children. Pediatr Clin N Am 31:757–771

    CAS  Google Scholar 

  7. McFadden ER (1984) Pathogenesis of asthma. J Allergy Clin Immunol 73:413–424

    Article  PubMed  CAS  Google Scholar 

  8. Siegel SC, Rachelefsky GS (1985) Asthma in infants and children I. J Allergy Clin Immunol 76:1–14

    Article  PubMed  CAS  Google Scholar 

  9. Dolovich J, Hargreave F (1981) The asthma syndrome: inciters, inducers and host characteristics. Thorax 36:641–644

    Article  Google Scholar 

  10. Larsen GL (1985) Late-phase reactions: Observations on pathogenesis and prevention. J Allergy Clin Immunol 76:665–669

    Article  PubMed  CAS  Google Scholar 

  11. Drug therapy for asthma. Jenne JW, Murphy S (1987) (eds). Lung biology in health and disease. Marcel Dekker, New York, Basel, Vol 31

  12. Beasley R, Rocke WR, Roberts JA, Holgate ST (1989) Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis 139:806–817

    PubMed  CAS  Google Scholar 

  13. Hargreave FE, Dolovich J, Newhouse MT (1990) The assessment and treatment of asthma: a conference report. J Allergy Clin Immunol (in press)

  14. Newman SP (1984) Therapeutic aerosols. In: Aerosols and the lung in clinical and experimental aspects. Clarke SW, Pavia D (eds) Butterworths, London, pp 197–224

    Google Scholar 

  15. Sleigh MA, Blake JR, Liron N (1988) The propulsion of mucus by cilia. Am Rev Respir Dis 137:726–741

    PubMed  CAS  Google Scholar 

  16. Kerrebijn KF Beta-agonists. In: Kaliner M, Barnes PJ, Persson CGA (eds) Asthma and airway hyperresponsiveness: pathophysiology and treatment. Lung biology in health and disease, Marcel Dekker, New York, Basel (in press)

  17. Jenne JW, Ahrens RC (1988) Pharmacokinetics of beta-adrenergic compounds. In: Kaliner MA, Barnes P (eds) The airways neural control in health and disease. Lung biology in health and disease, Vol. 33. Marcel Dekker, New York, Basel, pp 213–258

    Google Scholar 

  18. Goldie RG, Spina D, Henry PJ, Lulich KM, Paterson JW (1986) In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline. Br J Pharmacol 22:669–676

    CAS  Google Scholar 

  19. Ullman A, Svedmyr N (1988) Salmeterol, a new long-acting inhaled beta-2-adrenoceptor agonist: comparison with salbutamol in adult asthmatic patients. Thorax 43:674–678

    Article  PubMed  CAS  Google Scholar 

  20. Prendiville A, Green S, Silverman M (1987) Paradoxical response to nebulised salbutamol in wheezy infants assessed by partial expiratory flow-volume curves. Thorax 42:86–91

    Article  PubMed  CAS  Google Scholar 

  21. Van Essen-Zandvliet EEM, Kerrebijn KF. The effect of anti-asthma drugs on bronchial hyperresponsiveness. In: Allergic inflammatory mediators and bronchial hyperreactivity, Immunol Allergy Clin North Am (in press)

  22. Conolly ME, Jenne JW, Hui KK, Borst SE (1988) Beta-adrenergic tachyphylaxis (desensitization) and functional antagonism. In: Kaliner MA, Barnes PJ (eds) Lung biology in health and disease, Vol. 33. Marcel Dekker, New York, Basel, pp 259–296

    Google Scholar 

  23. Lindgren SB, Larsson S (1982) Inhalation of terbutaline sulphate through a conventional actuator or a pear shaped tube: effect and side effect. Eur J Respir Dis 63:504–509

    PubMed  CAS  Google Scholar 

  24. Lichtenstein LM, Margolis S (1968) Histamine release in vitro: inhibition by cathecholamines and methylxanthines. Science 161:902–903

    Article  PubMed  CAS  Google Scholar 

  25. Guillot G, Fornaris M, Bedier M, Orehek J (1984) Spontaneous and provoked resistance in isolated human bronchi. J Allergy Clin Immunol 74:713–718

    Article  PubMed  CAS  Google Scholar 

  26. Nielson CP, Crowley JJ, Morgan ME, Vestal RE (1988) Polymorphonuclear leukocyte inhibition by therapeutic concentrations of theophylline is mediated by cyclic-3′,5′-adenosine monophosphate. Am Rev Respir Dis 137:25–30

    PubMed  CAS  Google Scholar 

  27. Persson CGA (1988) Xanthines as antiinflammatory drugs. Letter. J Allergy Clin Immunol 81:615–616

    Article  CAS  Google Scholar 

  28. Martin GL, Atkins FC, Dunsky EH, Zweiman B (1980) Effects of theophylline, terbutaline and prednisone on antigen induced bronchospasm and mediator release. J Allergy Clin Immunol 66:204–212

    Article  PubMed  CAS  Google Scholar 

  29. Nissim JE, Bleecker ER, Norman PS, Menkes H, Permutt S, Rosenthal RR (1980) Failure of aminophylline pretreatment to prevent antigen-induced bronchospasm. J Allergy Clin Immunol 65:180

    Google Scholar 

  30. Pauwels R, van Rentherghem D, van der Straeten M, Johanneson N, Persson CGA (1985) The effect of theophylline and enprofylline on allergen-induced bronchoconstriction. J Allergy Clin Immunol 76:583–590

    Article  PubMed  CAS  Google Scholar 

  31. Mapp C, Boschetto P, Dal Vecchio L, Crescioli S, de Marzo N, Paleari D, Fabbri LM (1987) Protective effect of antiasthma drugs on late asthmatic reactions and increased airway responsiveness induced by toluene diisocyante in sensitized subjects. Am Rev Respir Dis 136:1403–1407

    PubMed  CAS  Google Scholar 

  32. Ellis EF (1984) Inhibition of exercise-induced asthma by theophylline. J Allergy Clin Immunol 73:690–692

    Article  PubMed  CAS  Google Scholar 

  33. Magnussen H, Reuss G, Jörris R (1988) Methylxanthines inhibit exercise-induced bronchoconstriction at low serum theophylline concentrations and in a dose-dependent fashion. J Allergy Clin Immunol 51:531–537

    Article  Google Scholar 

  34. Merland N, Cartier A, L’Archevèque J, Ghezzo H, Malo JL (1988) Theophylline minimally inhibits bronchoconstriction induced by dry cold air inhalation in asthmatic subjects. Am Rev Respir Dis 137:1304–1308

    PubMed  CAS  Google Scholar 

  35. Jenne JW (1987) Physiology and pharmacodynamics of the xanthines. In: Jenne JW, Murphy S (eds) Drug therapy for asthma. Lung biology in health and disease, Vol. 31. Marcel Dekker, New York, Basel, pp 297–334

    Google Scholar 

  36. Hendeles L, Messanari M, Weinberger M (1985) Update on the pharmacokinetics of theophylline. Chest 88 (Suppl.):103S-111S

    PubMed  CAS  Google Scholar 

  37. Kelly HW (1987) Theophylline toxicity. In: Jenne JW, Murphy S (eds) Drug therapy for asthma. Lung biology in health and disease, Vol. 31. Marcel Dekker, New York, Basel, pp 925–951

    Google Scholar 

  38. O’Driscoll BR, Taylor RJ, Horsley MG, Chambers DK, Bernstein A (1989) Nebulised salbutamol with and without ipratropium bromide in acute airflow obstruction. Lancet 1:1418–1420

    Article  PubMed  Google Scholar 

  39. Rebuck AS, Chapman KR, Abbound R (1987) Nebulised anticholinergic and sympathomimetic treatment of obstructive airways disease in the emergency room. Am J Med 82:59–64

    Article  PubMed  CAS  Google Scholar 

  40. Leung KBP, Flint KC, Brostoff J, Hudspith BN, Mc I Johnson N, Lan HYA, Liu WL, Pearce FL (1988) Effects of sodium cromoglycate and nedocromil sodium on histamine secretion from human lung mast cells. Thorax 43:756–761

    Article  PubMed  CAS  Google Scholar 

  41. Kay AB, Walsh GM, Moqbel R, MacDonald AJ, Nagakura T, Carroll MP, Richerson HB (1987) Disodium cromoglycate inhibits activation of human inflammatory cells in vitro. J Allergy Clin Immunol 80:1–8

    Article  PubMed  CAS  Google Scholar 

  42. Murphy S (1987) Cromolyn sodium. In: Jenne JW, Murphy S (eds) Drug therapy for asthma. Lung biology in health and disease, Vol. 31. Marcel Dekker, New York, Basel, pp 677–678

    Google Scholar 

  43. Moqbel R, Cromwell D, Walsh GM, Wardlaw AJ, Kurlak L, Kay AB (1988) Effects of nedocromil sodium (TiladeR) on the activation of human eosinophils and neutrophils and the release of histamine from mast cells. Allergy 43:268–276

    Article  PubMed  CAS  Google Scholar 

  44. Dannon M, Chavis C, Crastes de Paulet A, Michel FB, Godard P (1986) Effect of nedocromil sodium on TxB21, LTB4 and LTD4 synthesis by alveolar macrophages from asthmatic patients. Eur J Respir Dis 69(Suppl 147):206–209

    Google Scholar 

  45. Spry CFJ, Kumaraswani V, Tai PC (1986) The effect of nedocromil sodium on secretion from human eosinophils. Eur J Respir Dis 69 (Suppl 147):241–243

    Google Scholar 

  46. Horn CR, Jones RM, Lee D, Brennan SR (1984) Bronchodilator effect of disodium cromoglycate administered as a dry powder in exercise-induced asthma. Br J Pharmacol 18:798–801

    CAS  Google Scholar 

  47. Hasham F, Kennedy JD, Jones RS (1981) Actions of salbutamol, disodium cromoglycate and placebo administered as aerosols in acute asthma. Arch Dis Child 56:722–725

    Article  PubMed  CAS  Google Scholar 

  48. Dixon M, Jackson DM, Richards IM (1980) The action of sodium cromoglycate on “C” fibre endings in the dog lungs. Br J Pharmacol 70:11–13

    PubMed  CAS  Google Scholar 

  49. Joos GS, Pauwels RA, van der Straeten ME (1988) The mechanism of tachykinin induced bronchoconstriction in the rat. Am Rev Respir Dis 137:1038–1044

    PubMed  CAS  Google Scholar 

  50. Erjefält I, Persson CGA (1986) Anti-asthma drugs attenuate inflammatory leakage of plasma into airway lumen. Acta Physiol Scand 128:653–654

    Article  PubMed  Google Scholar 

  51. Church MK, Warner JO (1985) Sodium cromoglycate and related drugs. Clin Allergy 15:311–320

    Article  PubMed  CAS  Google Scholar 

  52. Mattoli S, Foresi A, Corbo GM, Valente S, Ciappi G (1987) Effects of two doses of cromolyn on allergen-induced late asthmatic response and increased responsiveness. J Allergy Clin Immunol 97:747–754

    Article  Google Scholar 

  53. Holgate ST (1986) Clinical evaluation of nedocromil sodium in the treatment of asthma. Eur J Respir Dis 69(Suppl 147):149–159

    Google Scholar 

  54. Murphy S (1987) Cromolyn sodium. In: Jenne JW, Murphy S (eds) Drug therapy for asthma. Lung biology in health and disease, Vol. 31. Marcel Dekker, New York, Basel, pp 688–690

    Google Scholar 

  55. Fuller RW, Collier JG (1984) Sodium cromoglycate and atropine block the fall in FEV1 but not the cough induced by hypotonic mist. Thorax 39:766–770

    Article  PubMed  CAS  Google Scholar 

  56. Sheppard D, Nadel JA, Boushey HA (1981) Inhibition of sulfur dioxide-induced bronchoconstriction by disodium cromoglycate in asthmatic subjects. Am Rev Respir Dis 124:257–259

    PubMed  CAS  Google Scholar 

  57. Chapter on preclinical safety and clinical pharmacology studies (1986). In: Inflammation: Its clinical relevance in airway diseases. Eur J Respir Dis 69(Suppl 147):246–304

    Google Scholar 

  58. Bel E, Timmers MC, Hermans J, Dijkman JH, Sterk PJ (1990) The long-term effects of nedocromil sodium and beclomethasone dipropionate on bronchial responsiveness to methacoline in non-atopic asthmatics. Am Rev Respir Dis 141:21–28

    PubMed  CAS  Google Scholar 

  59. Schleimer RP (1990) Effects of glucocorticosteroids on inflammatory cells relevant to their therapeutic applications in asthma. In: Kaliner M, Clark T (eds) Corticosteroids, their biologic mechanisms and application to the treatment of asthma. Am Rev Respir Dis (Suppl) (in press)

  60. Shenfield GM, Hodson ME, Clark SW, Paterson JW (1975) Interaction of corticosteroids and cathecholamines in the treatment of asthma. Thorax 30:430–435

    Article  PubMed  CAS  Google Scholar 

  61. Kerrebijn KF (1990) Use of topical corticosteroids in the treatment of childhood asthma. In: Kaliner M, Clark T (eds) Corticosteroids, their biologic mechanisms and application to the treatment of asthma. Am Rev Respir Dis (Suppl) (See ref 60)

  62. De Baets FM, Goeteyn M, Kerrebijn KF (1990) The effect of two months treatment with inhaled budesonide on the bronchial responsiveness to histamine and house-dust mite antigen in asthmatic children. Am Rev Respir Dis (in press)

  63. Dahl R, Johansson SA (1982) Importance of duration of treatment with inhaled budesonide on the immediate and late bronchial reaction. Eur J Respir Dis 63 (Suppl 122):167–175

    Google Scholar 

  64. Henriksen JM (1985) Effect of glucocorticosteroid inhalation therapy on exercise-induced asthma. Br Med J 291:248–249

    Article  CAS  Google Scholar 

  65. Lundgren R, Söderberg M, Hörstedt P, Stenling R (1988) Morphological studies of bronchial mucosal biopsies from asthmatics before and after ten years of treatment with inhaled steroids. Eur Respir J 1:883–889

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Paediatric Pulmonary Medicine, Erasmus University, Rotterdam, The Netherlands

    K. F. Kerrebijn MD, PhD

Authors
  1. K. F. Kerrebijn MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kerrebijn, K.F. Long-term drug treatment of asthma in children. Lung 168 (Suppl 1), 142–153 (1990). https://doi.org/10.1007/BF02718127

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02718127

Key words

Search

Navigation