Abstract
The presence of arginase in rat fibrosarcoma not synthesizing urea, suggested that this enzyme may have additional functions. Ornithine carbamoyl transferase, a key enzyme of the urea cycle was absent in this tissue, when compared to normal tissues, lower amount of ornithine was found in the fibrosarcoma, but this tumour contained a higher level of proline. The radioactivity present in L-[U-14C] arginine was incorporated into putrescine, spermidine, spermine, proline glutamate and glutamine suggesting that arginine was a possible precursor and that arginase may have a role in the synthesis of these metabolites.
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Gopalakrishna, R., Nagarajan, B. Arginase from rat fibrosarcoma. Its possible role in proline, glutamate and polyamine metabolism. J Biosci 2, 275–282 (1980). https://doi.org/10.1007/BF02716859
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DOI: https://doi.org/10.1007/BF02716859