Journal of Biosciences

, Volume 2, Issue 4, pp 275–282 | Cite as

Arginase from rat fibrosarcoma. Its possible role in proline, glutamate and polyamine metabolism

  • R. Gopalakrishna
  • B. Nagarajan


The presence of arginase in rat fibrosarcoma not synthesizing urea, suggested that this enzyme may have additional functions. Ornithine carbamoyl transferase, a key enzyme of the urea cycle was absent in this tissue, when compared to normal tissues, lower amount of ornithine was found in the fibrosarcoma, but this tumour contained a higher level of proline. The radioactivity present in L-[U-14C] arginine was incorporated into putrescine, spermidine, spermine, proline glutamate and glutamine suggesting that arginine was a possible precursor and that arginase may have a role in the synthesis of these metabolites.


Rat fibrosarcoma arginase ornithine carbamoyl transferase polyamines proline glutamate 


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Copyright information

© Indian Academy of Sciences 1980

Authors and Affiliations

  • R. Gopalakrishna
    • 1
  • B. Nagarajan
    • 1
  1. 1.Department of MicrobiologyCancer InstituteMadras

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