Advertisement

Journal of Biosciences

, Volume 6, Supplement 2, pp 93–96 | Cite as

Luteal function during the periimplantation period and requirement for estrogen for implantation and pregnancy maintenance in the non-human primate

  • N. R. Moudgal
Article

Abstract

An attempt has been made in this paper to review our present understanding of luteal function during the periimplantation period and in particular hormonal requirement for implantation and maintenance of early pregnancy in the non-human primate.

In a fertile cycle thecorpus luteum is apparently rescued from luteolysis by chorionic gonadotropin secreted by the implanted blastocyst, In the bonnet monkey the serum progesterone titers during the luteal phase of a fertile cycle seems higher compared to that of nonmated cycling monkeys. This suggested that thecorpus luteum is receiving some stimulatory signal from the blastocyst even prior to implantation. The recent demonstration that human blastocyst in culture secretes into the medium human chorionic gonadotropin essentially support the above assumption. However, attempts to extend the luteal phase of cycling unmated monkeys with exogenous human chorionic gonadotropin injection has hitherto not met with complete success suggesting that there could be other than chorionic gonadotropin, additional luteal stimulatory factors the unimplanted blastocyst is secreting.

Corpus luteum is the principle source of both progesterone and estrogen produced during the periimplantation period and dysruption of luteal function, brought about by either lutectomy or ovariectomy or luteinizing hormone antiserum treatment, followed by progesterone supplementation leads to maintenance of pregnancy. This has lead to questioning the need for estrogen in the maintenance of early pregnancy. Recent work using Zuclomiphene, an antiestrogen during days 5–11 of cycle in rhesus monkeys mated between day 9–14, has however, suggested that estrogen may be required for implantation. Further work is needed to arrive at an unequivocal decision regarding the need for estrogen in maintenance of early pregnancy in the primate.

Keywords

Estrogen implantation corpus luteum non-human primate 

Abbreviations used

CL

Corpus luteum

LH

luteinizing hormone

hCG

human chorionic gonadotropin

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adiga, P. R. and Ramana Murthy, C. V. (1983)Vitamin carrier proteins during embryonic development in birds and mammals in Molecular Biology of egg maturation, Ciba Foundation Symposium No. 98 (London: Pitman)p. 111.Google Scholar
  2. Atkinson, L. E., Hotchkiss, J., Fritz, G. R., Surve, A. H., Neill, J. D. and Knobil, E. (1975)Biol. Reprod.,12, 335.PubMedCrossRefGoogle Scholar
  3. Booher, G., Enders, A. C, Hendrickx, A. G. and Hess, D. L. (1981)Am. J. Anatomy,160, 17.CrossRefGoogle Scholar
  4. Bosu, W. T. K. and Johansson, E. D. B. (1975)Acta Endocrinol.,79, 598.PubMedGoogle Scholar
  5. Fishel, S. B., Edwards, R. G. and Avans, G. J. (1984)Science,223, 816.PubMedCrossRefGoogle Scholar
  6. Hearn, J. P. (1980) inImmunological aspects of Reproduction and Fertility Control, ed. J. P. Hearn (London: MTP Press) p.229.Google Scholar
  7. Hendrickx, A. G. and Enders, A. C. (1980) inNon human primate models for study of human reproduction, ed. T. C. Anand Kumar (Basel: S. Karger) p. 109.Google Scholar
  8. Meyer, R. K., Wolf, R. C. and Arslan, M. (1969) inHOFER Recent Advances in Primatology (Basel: S. Karger)2, 30.Google Scholar
  9. Moudgal, I. R., Mukku, O. R., Prahalada, S., Murty, G. S. R. C. and Li, C. H. (1978)Fertil. Steril. 30, 223.PubMedGoogle Scholar
  10. Mukku, V. R. and Moudgal, I. R. (1979) inRecent Advances in Reproduction and Regulation of Fertility, ed. G. P. Talwar. (Elsevier/North Holland) p. 135.Google Scholar
  11. Prahalada, S., Mukku, V. R., Rao, A. J. and Moudgal, I. R. (1975)Contraception,12, 137.PubMedCrossRefGoogle Scholar
  12. Prasad, I. R. I. and Sankaran, I. S. (1975)J. Sci. Ind. Res. (India),34, 336.Google Scholar
  13. Rao, A. J. and Moudgal, N. R. (1984)Gonadal hormonal profiles during the periimplantation period in the bonnet monkeys, Proceedings of the Indo-US Symposium on Ovum ImplantationICMRNew Delhi, p. 92.Google Scholar
  14. Saxena, B. B., Hasan, S. C., Haour, F. and Schmidt-Gollwitzer, M. (1974)Science,184, 793.PubMedCrossRefGoogle Scholar
  15. Sengupta, J., Paria, B. C. and Manchanda, S. K. (1981)J. Reprod. Fertil. 62, 437.PubMedCrossRefGoogle Scholar
  16. Sengupta, J., Roy S. E., Paria, B. C. and Manchanda, S. K.(1984)Role of embryonic estrogen during early gestation and implantation, Proceedings of the Indo-US Symposium on Ovum Implantation, ICMR, New Delhi, p. 54.Google Scholar
  17. Walsh, S. W., Wolf, R. G, Meyer, R. K. and Robinson, J. A. (1979)Biol. Reprod.,20, 606.PubMedCrossRefGoogle Scholar
  18. Wilks, J. W. and Noble, A. S. (1983)Endocrinology 112, 1256.PubMedCrossRefGoogle Scholar

Copyright information

© Indian Academy of Sciences 1984

Authors and Affiliations

  • N. R. Moudgal
    • 1
  1. 1.Center for Advanced Research in Reproductive Biology (ICMR), Laboratory of Endocrine Biochemistry, Department of BiochemistryIndian Institute of ScienceBangaloreIndia

Personalised recommendations