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Journal of Genetics

, Volume 83, Issue 1, pp 35–38 | Cite as

Refinement of the locus for non-syndromic sensorineural deafness (DFN2)

  • Bin Cui
  • Haibing Zhang
  • Yongzhong Lu
  • Wei Zhong
  • Gang Pei
  • Xiangyin Kong
  • Landian Hu
Research Article

Abstract

Non-syndromic X-linked deafness is a rare form of genetic deafness in humans accounting for a small proportion of all hereditary hearing loss. Different clinical forms of non-syndromic X-linked deafness have been described, and most of these have been mapped. Here, we report a Chinese family affected by a congenital profound sensorineural hearing loss. All phenotypes of this family are clinically compatible with non-syndromic sensorineural deafness (DFN2). A maximum two-point Lod score of 2.32 was obtained at markerDXS6797 (θ = 0.00). Recombinants define a region of 4.3 cm flanked by markersDXS6799 andGATA172D05. This region overlaps the previously reported DFN2 region by 2.0 cm.

Keywords

non-syndromic sensorineural deafness (DFN2) profound congenital sensorineural deafness linkage X chromosome 

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Copyright information

© Indian Academy of Sciences 2004

Authors and Affiliations

  • Bin Cui
  • Haibing Zhang
    • 1
  • Yongzhong Lu
    • 3
  • Wei Zhong
    • 1
  • Gang Pei
    • 1
    • 2
  • Xiangyin Kong
    • 1
  • Landian Hu
    • 1
  1. 1.Health Science Center, Shanghai Institutes for Biological SciencesChinese Academy of Sciences and Shanghai Second Medical UniversityShanghaiPeople’s Republic of China
  2. 2.Shenyang Pharmaceutical UniversityShenyangPeople’s Republic of China
  3. 3.Qingdao Medical CollegeQingdao Obstetrics and Gynecology HospitalQingdaoPeople’s Republic of China

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