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Subpopulations of T cells in lung biopsies from patients with pigeon breeder’s disease

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Abstract

Monoclonal antibodies were used to determine surface phenotypes of T cells in tissue obtained by open lung biopsies from patients with chronic hypersensitivity pneumonitis (pigeon breeder’s disease). The results indicate that an increased number of suppressor/cytotoxic cells is present in these patients when compared with the number of helper/inducer cells. These findings, which were present within the interstitium, are consistent with those found in bronchoalveolar lavage of patients with this disease. In addition, in two-thirds of the patients there was a greater total number of helper and suppressor cells than the total count for Pan T cells. A possible interpretation of these findings might be the presence of both markers in the same cell.

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Authors and Affiliations

  1. Unidad de Microscopía Electrónica, Facultad de Medicina, UNAM, and Instituto Nacional de Enfermedades Respiratorias, S.S.A., and INCIH, S.S.A., México, Mexico

    Roberto Barrios, Moisés Selman, Ramón Franco, Rocio Chapela, J. Sullivan López & Teresa I. Fortoul

Authors
  1. Roberto Barrios
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  2. Moisés Selman
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  3. Ramón Franco
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  4. Rocio Chapela
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  5. J. Sullivan López
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  6. Teresa I. Fortoul
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Barrios, R., Selman, M., Franco, R. et al. Subpopulations of T cells in lung biopsies from patients with pigeon breeder’s disease. Lung 165, 181–187 (1987). https://doi.org/10.1007/BF02714434

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  • DOI: https://doi.org/10.1007/BF02714434

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