To evaluate the possible role of immunogenetic factors as predisposing determinants of the development of asbestosis in exposed workers, we obtained 53 phenotypes of the human leucocyte antigen (HLA)-A, B, C, and DR antigens in 72 long-term workers of the mines and mills of Quebec and in a reference population of 150 residents. Among the asbestos workers, 32 did not have any abnormality and 40 had asbestosis. The 2 groups did not differ in term of age, exposure, or cigarette smoking habits. In agreement with previous reports, we found no significant change in frequency of the HLA-A, B, or C phenotypes. Furthermore, we did not find any significant change in the frequency of 10 phenotypes of the HLA-DR loci. We conclude that immunogenetic factors are not major predisposing determinants of asbestosis.
Key wordsAsbestosis Immunology HLA antigens
Unable to display preview. Download preview PDF.
- 1.Amos DB, Pool P (1976) HLA typing. In: Rose NR, Friedman H (eds) Manual of Clinical Immunology. American Society for Microbiology, Washington, DC, pp 797–804Google Scholar
- 4.Becklake MR, Fournier-Massey G, McDonald JC, Siemiatycky J, Rossiter CE (1970) Lung function in relation to chest roentgenographic changes in Quebec asbestos workers. Bull Eur Physiopathol Respir 6:637–659Google Scholar
- 15.Matej H, Lange A, Smolik R (1977) HLA antigens in asbestosis. Arch Immunol Ther Exp 25:489–491Google Scholar
- 17.Terasaki PI, ed (1980) Histocompatibility Testing. UCLA Tissue Typing Laboratory, Los Angeles, 18–20, 355, 509–511, 938Google Scholar