Comparative effect of epinephrine and aminophylline in the treatment of asthma
- 51 Downloads
Thirty-seven patients with severe asthma were randomized into three groups and treated double-blindly with either aminophylline, epinephrine, or a combination of these two for one hour and then with both drugs for an additional hour. All patients began with plasma theophylline levels less than 10 µg/ml and all achieved 17 µg/ml. Epinephrine produced 134% improvement in FEV1 in one hour compared to 38% improvement produced by aminophylline. Epinephrine and combination therapy produced the same amount of bronchodilatation in one hour. Patients whose initial PEFR was ≦100 l/min failed to improve with aminophylline alone. After two hours of treatment, there was no difference in FEV1 or PEFR among the three groups. Arrhythmias and vomiting occurred more frequently when aminophylline was used and these adverse responses did not correlate with plasma theophylline levels.
Key wordsEpinephrine Aminophylline Asthma treatment
Unable to display preview. Download preview PDF.
- 1.American Thoracic Society, Commmitee on diagnostic standards for nontuberculous respiratory disease (1962) Definitions and classifications of chronic bronchitis, asthma and pulmonary emphysema. Am Rev Respir Dis 85:762–768Google Scholar
- 5.Fuleihan FJD, Abdel-Baki N, Arslanian A (1969) The effect of intravenous aminophylline on pulmonary function. Chest 56:481–487Google Scholar
- 12.Kory RC, Pribek RA, Sternlieb RO (1958) Comparative evaluation of epinephrine and aminophylline as bronchodilator agents. Am Rev Respir Dis 77:729–736Google Scholar
- 26.Shim CS, Scher SM, Williams MH (1976) Effect of bronchodilator agents on arrhythmia. NY State J Med 76:1973–1976Google Scholar
- 27.Szentivanyi A, Fishel CW (1976) The Beta-adrenergic theory and cyclic-amp mediated control mechanisms in human asthma, Bronchial asthma. In: Weiss EB, Segal MS (eds) Mechanisms and therapeutics. Little Brown, Boston, p 137–154Google Scholar
- 28.Tai E, Read J: (1957) Response of blood gas tensions to aminophylline and isoprenaline in patients with asthma. Thorax 22:543–549Google Scholar
- 31.Winer BJ (1971) Statistical principles in experimental design, 2nd edn. McGraw Hill, New York, p 514Google Scholar
- 33.Zar JH (1971) Biostatistical analysis. Prentice-Hall Inc, Englewood Cliffs, New Jersey, p 151–155Google Scholar