, Volume 159, Issue 1, pp 43–49 | Cite as

Diabetic ketoacidosis and invasive aspergillosis

  • J. N. Grizzanti
  • A. Knapp


We report a case of diabetic ketoacidosis associated with invasive aspergillosis and no other known immunodeficiency. Immunologic studies revealed normal serum immunoglobulins and normal absolute numbers of T and B lymphocytes. Mitogenic responses of peripheral blood lymphocytes to multiple antigens (PPD, PHA, Con A, Streptodornase, Streptokinase, Candida) were within normal limits The clinical course was characterized by rapid improvement after control of diabetes and amphotericin therapy. Clinical observations and experimental evidence suggest that decreased granulocyte number and function predispose to invasive aspergillus infection. The pattern of immunodeficiency in the diabetic host is consistent with these abnormalities in that granulocyte function is impaired in diabetic acidosis.

Key words

Aspergillosis Immunodeficiency Diabetes 


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Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • J. N. Grizzanti
    • 1
  • A. Knapp
    • 2
  1. 1.Department of MedicineAlbert Einstein College of MedicineUSA
  2. 2.Department of MedicineBronx Municipal Hospital CenterBronxUSA

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