Advertisement

Lung

, Volume 159, Issue 1, pp 17–22 | Cite as

Bird fancier’s lung: Studies of broncho-alveolar lavage and correlations with inhalation provocation tests

  • C. Voisin
  • A. B. Tonnel
  • C. Lahoute
  • H. Robin
  • J. Lebas
  • C. Aerts
Article

Abstract

The cellular, biochemical and immunologic characteristics of lavage fluid collected from 9 patients with bird fancier’s lung and from 4 asymptomatic pigeon breeders of whom 3 had positive serum precipitating antibodies were compared with clinical, biological and functional pulmonary responses after inhalation provocation tests. In the symptomatic subjects, the lavage fluid consistently revealed a lymphocytosis (34% to 90%) with elevation of proteins and immunoglobulins G, A and M which varied with the severity of the disease. In 5 of 8 cases, precipitating antibodies to avian antigens were found. All 9 patients with fancier’s lung had a positive bronchial provocation test which was more intense in the acute stage of the disease. In the asymptomatic subjects there was no elevation in the percentage of alveolar fluid lymphocytes, and the bronchial provocation test induced no clinical, biological or functional changes.

Key words

Broncho-alveolar lavage Inhalation provocation test Bird fancier’s lung Hypersensitivity pneumonitis 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Biserte G, Chretien J, Voisin C (eds) (1979) Le lavage broncho-alvéolaire chez l’homme. Colloque inserm, 84:1–544Google Scholar
  2. 2.
    Hargraeve FE, Pepys J (1972) Allergic respiratory reactions in bird fanciers provoked by allergen inhalation provocation tests. Relation to clinical features and allergic mechanisms. J Allergy Clin Immunol 50:157–173CrossRefGoogle Scholar
  3. 3.
    Kazmierowski JA, Aduan RP, Reynolds HY (1977) Pulmonary host defense: coordinated interactions of mechanical, cellular and humoral immune systems of the lung. Bull Eur Physiopathol Respir 13:103–105PubMedGoogle Scholar
  4. 4.
    Pepys J., Hutchcroft B (1975) Bronchial provocation tests in etiologic diagnosis and analysis of asthma. Am Rev Respir Dis 112:829–859PubMedGoogle Scholar
  5. 5.
    Reynolds HY, Fulmer JD, Kazmierowski JA, Roberts WC, Frank MM, Crystal RG (1977) Analysis of cellular and protein content of broncho-alveolar fluid from patients with idiopathic pulmonary fibrosis and chronic hypersensitivity pneumonitis. J Clin Invest 59:165–175PubMedCrossRefGoogle Scholar
  6. 6.
    Roberts RC, Moore VL (1977) Immunopathogenesis of hypersensitivity pneumonitis. Am Rev Respir Dis 116:1075–1090PubMedGoogle Scholar
  7. 7.
    Voisin C, Tonnel AB, Aerts C, Lafitte JJ, Ramon P (1977) Les populations cellulaires des espaces aériens broncho-alvéolaires dans la sarcoïdose, les alvéolites allergiques extrinsèques et les cancers bronchiques. Nouv Presse Med 6:2685PubMedGoogle Scholar
  8. 8.
    Tonnel AB, Lahoute C, Lebas J, Robin H, Ramon P, Aerts C, Voisin C (1979) Caractéristiques cellulaires et biochimiques du lavage bronchoalvéolaire au cours du poumon d’éleveur d’oiseaux. Bronchoalveolar lavage in man. Colloques inserm 84:329–336Google Scholar

Copyright information

© Springer-Verlag 1981

Authors and Affiliations

  • C. Voisin
    • 1
  • A. B. Tonnel
    • 1
  • C. Lahoute
    • 1
  • H. Robin
    • 1
  • J. Lebas
    • 1
  • C. Aerts
    • 1
  1. 1.Hôpital Calmette and Institut Pasteur de LilleLilleFrance

Personalised recommendations