, Volume 161, Issue 1, pp 195–206 | Cite as

On paradigms, paradoxes, and particles

  • W. K. C. Morgan
  • H. W. Clague
  • S. Vinitski


Certain aspects of particle deposition and clearance from the lungs are discussed. Their role in the etiology of lung disease and in particular to the anatomical localization of the earliest pathological lesion is considered. Hypotheses are put forward to explain the topographical localization of dust diseases and emphysema. The need to devize methods of studying regional clearance of particles from the alveoli is stressed.

Key words

Particle deposition Lung clearance Regional ventilation Regional deposition Breathing patterns 


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  1. 1.
    Auerbach O, Saccomano G, Kuschner M, Brown RD, Garfinkel L (1978) Histologic findings in the trachebronchial tree of uranium miners and non-miners with lung cancer. Cancer 42:483–489PubMedCrossRefGoogle Scholar
  2. 2.
    Bake B, Wood L, Murphy B, Macklem PT, Milic-Emili J (1974) Effect of inspiratory flow on regional distribution of inspired gas. J Appl Physiol 37:8–17PubMedGoogle Scholar
  3. 3.
    Ball WC, Stewart PB, Newsham LG, Bates DV (1962) Regional pulmonary function studies with xenon-133. J Clin Invest 41:519–531PubMedCrossRefGoogle Scholar
  4. 4.
    Beeckmans JM (1965) The deposition of aerosol in the respiratory tract. Mathematical analysis and comparison with experimental data. Can J Physiol Pharmacol 43:157–172PubMedGoogle Scholar
  5. 5.
    Brain JD, Valberg PA (1979) Deposition of aerosol in the respiratory tract. Am Rev Respir Dis 120:1325–1373PubMedGoogle Scholar
  6. 6.
    Bryan AC, Bentivolglio LG, Beerel F, MacLeish H, Zidulka A, Bates DV (1964) Factors influencing regional distribution of ventilation and perfusion in the lungs. J Appl Physiol 19:395–402PubMedGoogle Scholar
  7. 7.
    Brundelet PJ (1965) Experimental study of the dust clearance mechanism of the lung. Acta Pathol Microbiol Scand 175:1–141Google Scholar
  8. 8.
    Camner P (1980) Clearance of particles from the human tracheobronchial tree. Clin Sci 59:79–84PubMedGoogle Scholar
  9. 9.
    Chamberlain MJ, Morgan WKC, Vinitski S (1983) Factors influencing the regional deposition of inhaled particles in man. Clin Sci 64:69–78PubMedGoogle Scholar
  10. 10.
    Cinkotai FF (1974) Fluid flow in a model alveolar sac. J Appl Physiol 37:249–251PubMedGoogle Scholar
  11. 11.
    Clague HW, Ahmad D, Chamberlain MJ, Morgan WKC, Vinitski S (1982) The effect of exercise on the regional distribution of inhaled particles. Abstract, International Conference on Occupational Lung Disease, American College of Chest Physicians, Chicago, Illinois, March 1982Google Scholar
  12. 12.
    Cockroft DW, Horne SL (1982) Localization of emphysema within the lung. An hypothesis based upon ventilation/perfusion relationships. Chest 82:483–487Google Scholar
  13. 13.
    Davies CN (1972) Breathing of half-micron aerosols. II. Interpretation of experimental results. J Appl Physiol 32:600–611Google Scholar
  14. 14.
    Davies CN (1972) An algebraical model for the deposition of aerosol in the human respiratory tract during steady state breathing. J Aerosol Sci 3:297–306CrossRefGoogle Scholar
  15. 15.
    Deal EC, McFadden ER, Ingram RH, Strauss RH, Jaeger JJ (1979) Role of respiratory heat exchange in production of exercise-induced asthma. J Appl Physiol 46:467–475PubMedGoogle Scholar
  16. 16.
    Dennis WL (1971) The effect of breathing rate on the deposition of particles in the human respiratory system. In: Walton WH (ed) Inhaled particles III. Unwin, Old Working, Surrey, pp 91–102Google Scholar
  17. 17.
    Ferron GA (1977) The size of soluble aerosol particles as a function of the humidity of the air. Application to the human respiratory tract. J Aerosol Sci 8:251–267CrossRefGoogle Scholar
  18. 18.
    Findeisen W (1935) Über das Absetzen kleiner in der Luft suspendierter Teilchen in der menschlichen Lunge bei der Atmung. Pflügers Arch 236:367–379CrossRefGoogle Scholar
  19. 19.
    Foord N, Black A, Walsh M (1978) Regional deposition of 2.5–7.5 µm diameter particles in healthy male non-smokers. J Aerosol Sci 9:343–357CrossRefGoogle Scholar
  20. 20.
    Green GM (1973) Alveolo-bronchiolar transport mechanisms. Arch Intern Med 131:109–114PubMedCrossRefGoogle Scholar
  21. 21.
    Gross P (1953) The mechanism of dust clearance from the lung. Am J Clin Pathol 23:116–120Google Scholar
  22. 22.
    Hamill P (1979) Particle deposition due to turbulent diffusion in the upper respiratory system. Health Phys 36:355–369PubMedGoogle Scholar
  23. 23.
    Hatch TF (1959) Respiratory dust retention and elimination. In: Orenstein AJ (ed) Proceedings of the Pneumoconiosis Conference, Johannesburg, Churchill Livingstone, London, pp 113–132Google Scholar
  24. 24.
    Heyder J, Davies CN (1971) The breathing of half micron aerosols. III. Disposition of particles in the respiratory tract. J Aerosol Sci 2:437–452CrossRefGoogle Scholar
  25. 25.
    Heyder J, Gebhart J, Roth C, Stahlhofen W, Stuck B, Tarroni G, DeZaiacomo T, Formignani M, Melandri C, Prodi V (1978) Intercomparison of lung deposition data for aerosol particles. J Aerosol Sci 9:147–155CrossRefGoogle Scholar
  26. 26.
    Horsfield K, Cumming G (1968) Morphology of the bronchial tree in man. J Appl Physiol 24:373–383PubMedGoogle Scholar
  27. 27.
    Horsfield K, Dart G, Olson DE, Filley GF, Cumming G (1971) Models of the human bronchial tree. J Appl Physiol 31:207–217PubMedGoogle Scholar
  28. 28.
    Ingham DB (1981) Precipitation of charged particles in human airways. J Aerosol Sci 12:131–135CrossRefGoogle Scholar
  29. 29.
    Kilburn KH (1968) A hypothesis for pulmonary clearance and its implications. Am Rev Respir Dis 98:449–463PubMedGoogle Scholar
  30. 30.
    Landahl HD (1950) On the removal of airborne droplets by the human respiratory tract. I. The lung. Bull Math Biophys 12:43–56CrossRefGoogle Scholar
  31. 31.
    Landahl H (1963) Particle removal by the respiratory system. Bull Math Biophys 25:29–39PubMedCrossRefGoogle Scholar
  32. 32.
    Lew HS, Fung YC (1969) On the low Reynolds numbers entry flow into the circular cylindrical tube. J Biochem 2:105–119Google Scholar
  33. 33.
    Line DH, Deeley TJ (1971) The necropsy findings in carcinoma of the bronchus. Br J Dis Chest 65:238–242PubMedCrossRefGoogle Scholar
  34. 34.
    Lippman M, Yeates DB, Albert RE (1980) Deposition, retention and clearance of inhaled particles. Br J Ind Med 37:337–362Google Scholar
  35. 35.
    Mercer TT (1967) On the role of particle size in the dissolution of lung burdens. Health Phys 13:1211–1221PubMedCrossRefGoogle Scholar
  36. 36.
    Morgan WKC (1982) The effects of particles, vapours, fumes and gases. Eur J Respir Dis [Suppl] 63:7–12Google Scholar
  37. 37.
    Muir DC, Davies CN (1967) The deposition of 0.5 µm diameter aerosols in the lungs of man. Ann Occup Hyg 10:161–174PubMedGoogle Scholar
  38. 38.
    Muir DCF, Sweetland K, Love RG (1971) Inhaled aerosol boluses in man. In: Walton WH (ed) Inhaled particles III. Gresham Press, pp 81–89Google Scholar
  39. 39.
    Niinimaa VMJ (1979) Oral nasal distribution of respiratory airflow. PhD dissertation, University of TorontoGoogle Scholar
  40. 40.
    United States Occupational Safety and Health Administration, Department of Labor (1974) Field memorandum no 74–92. US Government Printing Office, Washington, DCGoogle Scholar
  41. 41.
    Olson DE, Sudlow MF, Horsfield K, Filley GF (1973) Convective patterns of flow during inspiration. Arch Intern Med 131:51–57PubMedCrossRefGoogle Scholar
  42. 42.
    Pedley TJ, Schroter RC, Sudlow MF (1977) Gas flow and mixing in the airways. In: West JB (ed) Bioengineering aspects of the lung. Marcel Dekker, New York, pp 163–268Google Scholar
  43. 43.
    Proctor DF (1977) The upper airways. I. Nasal physiology and defense of the lung. Am Rev Respir Dis 115:97–129PubMedGoogle Scholar
  44. 44.
    Raabe OG (1982) Deposition and clearance of inhaled aerosols. In: Witschi H, Nettesheim P (eds) Mechanisms in respiratory toxicology, vol 1. CRC Press, Boca Raton, Fla, p 27Google Scholar
  45. 45.
    Schursch S, McIver D (1981) Surface tension at low lung volumes. Dependence on time and alveolar size. Biophys J 33:201aGoogle Scholar
  46. 46.
    Seaton D, Ogilvie C (1978) Regional lung function in asymptomatic cigarette smokers. Am Rev Respir Dis 118:265–269PubMedGoogle Scholar
  47. 47.
    Stahlhofen W, Gebhart J, Heyder J (1980) Experimental determination of the regional deposition of aerosol particles in the human respiratory tract. Am Ind Hyg Assoc J 41:385–399PubMedGoogle Scholar
  48. 48.
    Task Force Group on Lung Dynamics, Committee II - IRCP (1966) Deposition and retention models for inhaled dosimetry of the human respiratory tract. Health Phys 12:173–208Google Scholar
  49. 49.
    Timbrell V, Skidmore JW (1977) The effect of shape on particle penetration and retention of animal lungs. In: Walton WH (ed) Inhaled particles IV. Pergamon Press, New York, pp 49–57Google Scholar
  50. 50.
    Weibel ER (1963) Morphometry of the human lung. Academic Press, New York LondonGoogle Scholar
  51. 51.
    West JB (1962) Regional differences in gas exchange in the lung of erect man. J Appl Physiol 17:893–898PubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH & Co KG 1983

Authors and Affiliations

  • W. K. C. Morgan
    • 1
  • H. W. Clague
    • 1
  • S. Vinitski
    • 1
  1. 1.University HospitalUniversity of Western OntarioLondonCanada

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