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Lung

, Volume 158, Issue 1, pp 15–23 | Cite as

The site of action of aβ 2-receptor stimulating drug (Fenoterol) on antigen-induced bronchoconstriction

  • I. Zimmermann
  • A. A. Bugalho de Almeida
  • W. T. Ulmer
Article

Abstract

The influence of Fenoterol administered to the upper and lower area of the air conducting system on antigen-induced bronchoconstriction was studied in 60 dogs. In small doses, Fenoterol administered to the upper airways blocked bronchoconstriction by antigen applied to upper but not to lower airways. The intravenous administration of the same dose was without effect. In large doses, Fenoterol blocked bronchoconstriction induced at both sites. Application of both doses of Fenoterol to lower airways blocked bronchoconstriction induced at both sites and was more effective than intravenous treatment.

We concluded that there is an important local effect of Fenoterol on the upper respiratory tract in antigen-induced bronchoconstriction from this site as well as on the lower airways.

Key words

Air conducting system Antigen-induced bronchoconstriction 

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Copyright information

© Springer-Verlag 1980

Authors and Affiliations

  • I. Zimmermann
    • 1
  • A. A. Bugalho de Almeida
    • 1
  • W. T. Ulmer
    • 1
  1. 1.Medizinische Universitätsklinik und Poliklinik der Berufsgenossenschaftlichen Krankenanstalten „Bergmannsheil Bochum“BochumFederal Republic of Germany

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