Abstract
We present the case of a 69 years old woman who underwent chemotherapy and mantle radiotherapy for non Hodgkin lymphoma. Fifteen years later, she underwent mastectomy for breast mass that was diagnosed as an osteosarcoma at final pathological examination. Radical surgery was the only treatment she received.
Postirradiation breast sarcoma are rare and have poorer prognosis than primary breast sarcomas. Surgery is the main treatment. The use of adjuvant treatment is controversial, but there are some data that support the use of chemotherapy in these sarcomas.
Similar content being viewed by others
Bibliografía
Andrea K, Bernard MV, Weller E, et al. Second malignancy after Hodgkin disease treated with radiation therapy with or without chemotherapy: long-term risks and risk factors. Blood 2002; 100(6):1989–96.
Cahan WG, Woodward HQ, Higingbotham NL, et al. Sarcoma arising in irradiated bone: report of eleven cases. Cancer 1948;1:3–29.
Silver SA, Taassoli FA. Primary osteogenic sarcoma of the breast. A clinicopathologic analysis of 50 cases. Am J Surg Pathol 1998;22(8):925–33.
Gutman H, Pollock RE, Ross MI, et al. Sarcoma of the breast: Implications for extent of therapy. The M.D. Anderson experience. Surgery 1994;116:505–9.
Zelek L, Llombart-Cussac A, Terrier P, et al. Prognostic factors in primary breast sarcomas: A series of patient with long-term follow up. J Clin Oncol 2003;21:2583–8.
Yap J, Chuba PJ, Thomas R, et al. Sarcoma as a second malignancy after treatment for breast cancer. Int J Radiat Oncol Biol Phys 2002;52(5):1231–7.
Laskin WB, Silverman TA, Ezinger FM, et al. Postradiation soft tissue sarcomas. An analysis of 53 cases. Cancer 1988;62(11):2330–40.
Pendlebury SC, Bilous M, Langlands AO. Sarcomas following radiation therapy for breast cancer: a report of three cases and a review of the literature. Int J Radiat Oncol Biol Phys 1995;31(2):405–10.
Ahmad SA, Patel SR, Ballo MT, et al. Extraosseous osteosarcoma: response to treatment and long-term outcome. J Clin Oncol 2002; 20(2):521–7.
Sarcoma Meta-analysis Collaboration. Adjuvant chemotherapy for localised resectable soft-tisue sarcoma of adults: meta-analysis of individual data. Lancet 1997;350:1647–54.
Frustaci S, Gherlinzoni F, De Paoli A, et al. Adjuvant chemotherapy for adult soft tissue sarcomas of the extremities and girdles: Results of the Italian Randomized Cooperative Trial. J Clin Oncol 2001; 19:1238–47.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Zotano, Á.G., Bertrán, A.S. & Gandía, B.M. Osteosarcoma de mama posradioterapia. Rev Oncol 6, 488–490 (2004). https://doi.org/10.1007/BF02713086
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02713086