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Radioquimioterapia de la enfermedad limitada del carcinoma pulmonar de célula pequeña. ¿Tratamiento concomitante en protocolos asistenciales?

Combined radiochemotherapy in localised small-cell lung cancer. Concurrent treatment protocols?

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Abstract

Purpose

We retrospectively reviewed our institution’s database to investigate the outcome and impact of combined radiochemotherapy (RT/CT; concomitant or in sequence) in localised small-cell lung cancer (L-SCLC).

Material and methods

Between January 1995 to November 1999, 79 patients with L-SCLC received combined RT/CT at our Institution. RT was delivered concurrently or sequentially following the CT. Patients with treatment response received additional prophylactic cranial irradiation (PCI).

Results

Of the patients treated, 54% had received concurrent CT/RT compared to 46% receiving RT following the CT. PCI was administered to 80% of the patients. Complete response was observed in 66% of patients. With a median follow up of 30 months, median overall survival was 15.9 months; 14.3 months for patients who received RT following CT and 21.6 months for those receiving concurrent CT/RT. The type of schedule of combined radiochemotherapy was an independent prognostic factor for survival free of local recurrence, as was additional PCI for distant metastasis-free survival.

Conclusions

Our results are similar to those reported previously in the literature. The main point of interest is that our patients were non-selected. We strongly support the use of concurrent CT/RT so as to achieve results comparable to the best in the literature.

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Authors and Affiliations

  1. Servicio de Oncología Médica, Institut Català d'Oncología, Barcelona, España

    Ana Montes Borinaga & Felipe Cardenal Alemany

  2. Servicio de Oncología Radioterápica. Klinikum rechts der Isar, Technical University, Munich, Alemania

    Branislav Jeremic

  3. Servicio de Oncología Radioterápica, Institut Català d'Oncologia, Av. Gran Vía s/n, km 2.7, 08907, L'Hospitalet. Barcelona

    Ana Lucas Calduch, María Dolores Arnaiz Fernández, Sol San José Maderuelo, Valentí Navarro Pérez, Gala Serrano Bermúdez & Ferran Guedea Edo

Authors
  1. Ana Lucas Calduch
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  2. María Dolores Arnaiz Fernández
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  3. Sol San José Maderuelo
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  4. Valentí Navarro Pérez
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  5. Gala Serrano Bermúdez
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  6. Ana Montes Borinaga
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  7. Felipe Cardenal Alemany
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  8. Branislav Jeremic
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  9. Ferran Guedea Edo
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Correspondence to Ana Lucas Calduch.

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Calduch, A.L., Arnaiz Fernández, M.D., José Maderuelo, S.S. et al. Radioquimioterapia de la enfermedad limitada del carcinoma pulmonar de célula pequeña. ¿Tratamiento concomitante en protocolos asistenciales?. Clin Transl Oncol 7, 314–320 (2005). https://doi.org/10.1007/BF02710271

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  • DOI: https://doi.org/10.1007/BF02710271

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