Journal of Biosciences

, Volume 26, Issue 4, pp 429–435 | Cite as

Molecular insights into the causes of male infertility

  • Polani B. Seshagiri


Infertility is a reproductive health problem that affects many couples in the human population. About 13–18% of couple suffers from it and approximately one-half of all cases can be traced to either partner. Regardless of whether it is primary or secondary infertility, affected couples suffer from enormous emotional and psychological trauma and it can constitute a major life crisis in the social context. Many cases of idiopathic infertility have a genetic or molecular basis. The knowledge of the molecular genetics of male infertility is developing rapidly, new “spermatogenic genes” are being discovered and molecular diagnostic approaches (DNA chips) established. This will immensely help diagnostic and therapeutic approaches to alleviate human infertility. The present review provides an overview of the causes of human infertility, particularly the molecular basis of male infertility and its implications for clinical practice.


Fertility genes infertility medically assisted reproductive technology Y-chromosome 

Abbreviations used


Azoospermia factor


cystic fibrosis transmembrane conductance regulator


deleted in azoospermia


fluorescent in situ hybridization


intra-cytoplasmic sperm injection


medically assisted reproductive technology


RNA-binding motif


sexually transmitted diseases


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Copyright information

© Indian Academy of SciencesIndian Academy of Sciences 2001

Authors and Affiliations

  • Polani B. Seshagiri
    • 1
  1. 1.Department of Molecular Reproduction, Development and GeneticsIndian Institute of ScienceBangaloreIndia

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