Journal of Biosciences

, Volume 11, Issue 1–4, pp 239–244 | Cite as

RNase F and 2′,5′-oligoA synthetase activities in mice after poly(I). poly(C) administration

  • Krishna Baksi
  • Boris Skurkovich
  • Simon Skurkovich


The present study demonstrates the presence of considerable levels of 2′, 5′-oligoA synthetase activity in tissue extracts from mice. The interferon inducer, poly(I) .poly(C) , induced the synthetase activity in all the tissue extractsin vivo. Similarly, a significant amount of endonuclease RNase F activity is found to be present in these tissue extracts. But interferon induction does not seem to have any significant effect on RNase F activity.


RNase 2′,5′-oligoA synthetase activity poly(I).poly(C) administration 


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Copyright information

© Indian Academy of Sciences 1987

Authors and Affiliations

  • Krishna Baksi
    • 1
  • Boris Skurkovich
    • 1
  • Simon Skurkovich
    • 1
  1. 1.Laboratory of Cell Biology and GeneticsNational Institute of Arthritis, Diabetes, and Digestive and Kidney Diseases, National Institutes of HealthBethesdaUSA

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