RNase F and 2′,5′-oligoA synthetase activities in mice after poly(I). poly(C) administration
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The present study demonstrates the presence of considerable levels of 2′, 5′-oligoA synthetase activity in tissue extracts from mice. The interferon inducer, poly(I) .poly(C) , induced the synthetase activity in all the tissue extractsin vivo. Similarly, a significant amount of endonuclease RNase F activity is found to be present in these tissue extracts. But interferon induction does not seem to have any significant effect on RNase F activity.
KeywordsRNase 2′,5′-oligoA synthetase activity poly(I).poly(C) administration
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