Abstract
Ultrasonic radiation produced a dose-dependent linear increase in lipid peroxidation in the liposomes membrane as reflected in the measurement of conjugated dienes, lipid hydroperoxides and malondialdehydes. Ultrasound induced malondialdehyde production could not be inhibited by any significant degree by superoxide dismutase or histidine or dimethyl furan but was very significantly inhibited by butylated hydroxytoluene, cholesterol, sodium benzoate, dimethyl sulphoxide, sodium formate and EDTA. The scavenger studies indicated the functional role of hydroxyl radicals in the initiation of ultrasound induced lipid peroxidation.
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Abbreviations
- MDA:
-
Malondialdehyd
- DMSO:
-
dimethyl sulphoxide
- SOD:
-
superoxide dismutase
References
Banerjee, S. and Chatterjee, S. N. (1983)Z. Naturforsch.,38c, 302.
Blazek, E. R. and Peak, M. J. (1988)Int. J. Radiat. Biol.,53, 237.
Chatterjee, S. N. and Agarwal, S. (1988)Free Radical Biol. Med.,4, 51.
Coakley, W. T. and Nyborg, W. L. (1978) inUltrasound: Its applications in medicine and biology (ed. F. J. Fry) (Amsterdam: Elsevier) p. 77.
Edmonds, P. D. and Sander, K. M. (1983)Ultrasounds Med. Biol.,9, 635.
Fricke, H. and Hart, E. J. (1966) inRadiation dosimetry (eds F. H Attix and W. C. Roesch) (New York: Academic Press) vol. 2, p. 167.
Hill, C. R. (1968) Br.J. Radiol., 41., 561.
Jana, A. K., Agarwal, S. and Chatterjee, S. N. (1986)Radiat. Environ. Biophys.,25, 309.
Kremkau, F. W. (1989)J. Clin. Ultrasounds,7, 287.
Makino, K., Mossaba, M. M. and Riesz, P. (1983)J. Phys. Chem.,87, 1369.
Pryor, W. A. (1976)Free radicals in biology, volumes 1–5 (New York: Academic Press).
Szebeni, J. and Toth, K. (1986)Biochim. Biophys. Acta,857, 139.
Tien, M., Morehouse, L. A., Bucher, J. R. and Aust, S. D. (1982)Arch. Biochem. Biophys.,218, 450.
Valenzeno, D. P. (1987)Photochem. Photobiol.,46, 147.
Yagi, K. (1982)Lipid peroxides in biology and medicine (New York: Academic Press).
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Jana, A.K., Agarwal, S. & Chatterjee, S.N. Membrane lipid peroxidation by ultrasound: Mechanism and implications. J Biosci 15, 211–215 (1990). https://doi.org/10.1007/BF02703887
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DOI: https://doi.org/10.1007/BF02703887