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Journal of Biosciences

, Volume 15, Issue 3, pp 211–215 | Cite as

Membrane lipid peroxidation by ultrasound: Mechanism and implications

  • A. K. Jana
  • S. Agarwal
  • S. N. Chatterjee
Article

Abstract

Ultrasonic radiation produced a dose-dependent linear increase in lipid peroxidation in the liposomes membrane as reflected in the measurement of conjugated dienes, lipid hydroperoxides and malondialdehydes. Ultrasound induced malondialdehyde production could not be inhibited by any significant degree by superoxide dismutase or histidine or dimethyl furan but was very significantly inhibited by butylated hydroxytoluene, cholesterol, sodium benzoate, dimethyl sulphoxide, sodium formate and EDTA. The scavenger studies indicated the functional role of hydroxyl radicals in the initiation of ultrasound induced lipid peroxidation.

Keywords

Ultrasound liposomes lipid peroxidation hydroxyl radicals scavengers 

Abbreviations used

MDA

Malondialdehyd

DMSO

dimethyl sulphoxide

SOD

superoxide dismutase

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References

  1. Banerjee, S. and Chatterjee, S. N. (1983)Z. Naturforsch.,38c, 302.Google Scholar
  2. Blazek, E. R. and Peak, M. J. (1988)Int. J. Radiat. Biol.,53, 237.CrossRefGoogle Scholar
  3. Chatterjee, S. N. and Agarwal, S. (1988)Free Radical Biol. Med.,4, 51.CrossRefGoogle Scholar
  4. Coakley, W. T. and Nyborg, W. L. (1978) inUltrasound: Its applications in medicine and biology (ed. F. J. Fry) (Amsterdam: Elsevier) p. 77.Google Scholar
  5. Edmonds, P. D. and Sander, K. M. (1983)Ultrasounds Med. Biol.,9, 635.CrossRefGoogle Scholar
  6. Fricke, H. and Hart, E. J. (1966) inRadiation dosimetry (eds F. H Attix and W. C. Roesch) (New York: Academic Press) vol. 2, p. 167.Google Scholar
  7. Hill, C. R. (1968) Br.J. Radiol., 41., 561.CrossRefGoogle Scholar
  8. Jana, A. K., Agarwal, S. and Chatterjee, S. N. (1986)Radiat. Environ. Biophys.,25, 309.CrossRefGoogle Scholar
  9. Kremkau, F. W. (1989)J. Clin. Ultrasounds,7, 287.CrossRefGoogle Scholar
  10. Makino, K., Mossaba, M. M. and Riesz, P. (1983)J. Phys. Chem.,87, 1369.CrossRefGoogle Scholar
  11. Pryor, W. A. (1976)Free radicals in biology, volumes 1–5 (New York: Academic Press).Google Scholar
  12. Szebeni, J. and Toth, K. (1986)Biochim. Biophys. Acta,857, 139.PubMedCrossRefGoogle Scholar
  13. Tien, M., Morehouse, L. A., Bucher, J. R. and Aust, S. D. (1982)Arch. Biochem. Biophys.,218, 450.PubMedCrossRefGoogle Scholar
  14. Valenzeno, D. P. (1987)Photochem. Photobiol.,46, 147.PubMedGoogle Scholar
  15. Yagi, K. (1982)Lipid peroxides in biology and medicine (New York: Academic Press).Google Scholar

Copyright information

© Indian Academy of Sciences 1990

Authors and Affiliations

  • A. K. Jana
    • 1
  • S. Agarwal
    • 1
  • S. N. Chatterjee
    • 1
  1. 1.Biophysics DivisionSaha Institute of Nuclear PhysicsCalcuttaIndia

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