Lipids in biological membranes generally adopt bilayer structures. However, incorporation of peptides may induce alterations in such structures. We have studied the influence of tryptophan, leucine, Trp-Leu, luteinizing hormone releasing hormone and renin inhibitor peptide on lipid organisation in liposomes. It has been observed that the effect is specific to the peptide molecule as-a whole and does not have direct correlation to the constituent amino acids or the conformation of the molecule.
KeywordsPeptides phosphorous NMR polymorphism electron microscopy liposomes
Electron spin resonance
dipalmytoyl phosphatidyl choline
chemical shift anisotropy
luteinizing hormone releasing hormone
renin inhibitor polypeptide
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