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Journal of Biosciences

, Volume 25, Issue 4, pp 397–404 | Cite as

Mechanism of store-operated calcium entry

  • Devkanya Dutta
Mini Review

Abstract

Activation of receptors coupled to the phospholipase C/IP3 signalling pathway results in a rapid release of calcium from its intracellular stores, eventually leading to depletion of these stores. Calcium store depletion triggers an influx of extracellular calcium across the plasma membrane, a mechanism known as the store-operated calcium entry or capacitative calcium entry. Capacitative calcium current plays a key role in replenishing calcium stores and activating various physiological processes. Despite considerable efforts, very little is known about the molecular nature of the capacitative channel and the signalling pathway that activates it. This review summarizes our current knowledge about store operated calcium entry and suggests possible hypotheses for its mode of activation.

Keywords

Capacitative calcium entry ICRAC IP3 signalling TRP 

Abbreviations used

ER

Endoplasmic reticulum

PLC

phospholipase C

PIP

phosphatidylinositol (4,5) biphosphate

IP3

inosi-tol-1,4,5-trisphosphate

SOC

store operated calcium channel

TRP

transient receptor potential

CIF

calcium influx factor

DHPR

dihydropyridine receptor

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Copyright information

© Indian Academy of Sciences 2000

Authors and Affiliations

  • Devkanya Dutta
    • 1
  1. 1.National Centre for Biological SciencesGKVKBangaloreIndia

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