Journal of Biosciences

, Volume 21, Issue 3, pp 313–327 | Cite as

Retinoic acid and mammalian craniofacial morphogenesis

  • Noriko Osumi-Yamashita


Retinoic acid is a morphogenetic signalling molecule in vertebrate embryos, one being known to perform a specific function in organizing the body pattern along the anteroposterior axis. This molecule has especially attracted research attention because retinoic acid treatment will also induce abnormal morphogenesis, particularly in the craniofacial structures. The present review discusses recent molecular insights revealing how the retinoic acid signal is transduced within a cell, specifically focusing on the involvement of cranial neural crest cells in retinoic acid-induced abnormal morphogenesis in the mammalian head


Retinoic acid (RA) mammalian embryos craniofacial morphogenesis neural crest cells facial primordia retinoic acid receptors retinoid X receptors cellular retinoid binding proteins Hox genes 


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Copyright information

© Indian Academy of Sciences 1996

Authors and Affiliations

  • Noriko Osumi-Yamashita
    • 1
  1. 1.Department of Developmental Biology, Division of Life Science of Maxillo-Facial Systems, Graduate School of DentistryTokyo Medical and Dental UniversityTokyoJapan

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