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Journal of Biosciences

, Volume 3, Issue 3, pp 221–226 | Cite as

Chemical modification of bacitracin A and the biological activity of modified bacitracins

  • S. Rambhav
Article

Abstract

The single side chain amino group of the D-ornithine residue in bacitracin seems to be important for the antibacterial activity of the molecule, since, acetylation, formylation, carbamylation and deamination of the antibiotic caused 90–92% loss of antibacterial activity. In contrast, nearly 80–91% of the antibacterial activity of the parent antibiotic was retained after the esterification, amide formation and acid-chloride formation of the α—and Y -carboxyl groups of D-asparagine and D-glutamic acid residues of the antibiotic, respectively.

Keywords

Bacitracin chemical modification formylation acetylation carbamylation deamination esterification 

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Copyright information

© Indian Academy of Sciences 1981

Authors and Affiliations

  • S. Rambhav
    • 1
  1. 1.Department of BiochemistryOsmania UniversityHyderabad

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